• Overall survival [ Time Frame: 60 months ]
  "From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 60 months").
• Progression free survival [ Time Frame: 60 months ]
  "From date of randomization until the date of first documented progression assessed up to 60 months").
• Larynx Preservation [ Time Frame: 24 months after treatment initiation ]
  From date of randomization up to 24 months evaluated by dynamic deglutition videoscopy
• Feasibility of salvage surgery [ Time Frame: 60 months after randomization ]
  Assessing the number of recurrences that could be successfully treated with salvage surgery and description of postoperative

In patients with tumors classified as T3 or T4 larynx and hypopharynx, the usually recommended treatment was total laryngectomy.This intervention allows to obtain locoregional disease control in 75% of cases, without laryngectomy

TPF arm followed by radiotherapy was validated in a Phase III (GORTEC 2000-01), it will be the standard treatment.

The RTOG study concluded that chemotherapy administrated during radiotherapy became a standard of laryngeal preservation.

Taking together all these considerations, it is necessary to perform a direct comparison in a randomized trial to further test this hypothesis. Chemotherapy followed by radiotherapy will be the standard arm. It hopes to increase the survival rate from 52% to 65% in the experimental arm.

• Drug: Docetaxel
  Docetaxel 75 mg / m² administered on day 1 of each cycle every 3 weeks as an intravenous (IV) infusion of one hour followed by cisplatin 75 mg / m² administered on day 1 hour infusion followed by 5-FU, 750 mg / m² / day administered in continuous infusion from D1 to D5 (or 120 hours)
  Other Name: Taxotere
• Drug: Cisplatin
  Cisplatin: 75 mg/m² for experimental arm and 100mg/m² for comparator arm administered on day 1 of each cycle every 3 weeks as an intravenous (IV) infusion.
  Other Name: Cisplatine
• Drug: Fluorouracil
  5-FU, 750 mg / m² / day administered in continuous infusion from D1 to D5 (or 120 hours)
  Other Name: 5 FU
• Radiation: radiotherapy
  Radiotherapy : 70Gy (2Gy/day) for 7 weeks.
  Other Name: radiation therapy

• Active Comparator: TPF followed by radiotherapy

  Induction chemotherapy by Docetaxel 75 mg/m² day 1,cisplatin 75 mg/m² day 1 and 5 fluorouracil 750mg/m²(day 1 to day 5) 3 cycles day1, day 22, day 43 followed (for responders or stable disease patients) by radiotherapy

  Radiotherapy ;70 gray fractionization: 2Gy/day, 5days/week, for 7 weeks.

  Interventions:

  • Drug: Docetaxel
  • Drug: Cisplatin
  • Drug: Fluorouracil
  • Radiation: radiotherapy
• Experimental: Cisplatin and radiotherapy

  Drug and radiation • Cisplatin: 100 mg / m² administered IV at J1, J22 and J43 of radiotherapy

  . Radiotherapy 70 gray fractionization: 2Gy/day, 5days/week, for 7 weeks.

  Interventions:

  • Drug: Cisplatin
  • Radiation: radiotherapy

Inclusion Criteria:

• Squamous cell carcinoma of the larynx or hypopharynx, histologically proven, locally advanced:

  • T2 not accessible to a supra-cricoid partial laryngectomy or not,
  • T3 without massive infiltration by endolarynx transglottic injury,
  • N0 to N2c
  • No distant metastasis
  • No associated cancer or earlier
• Patients Previously Untreated
• Age> 18 years and <75 years
• PS 0 or 1 according to WHO
• Tumor volume assessable by RECIST.
• Absence of distant metastasis, confirmed by chest TDM, abdominal ultrasound (or TDM) in case of abnormal liver function and bone scan if local symptoms.
• Absence of any participation in a clinical trial within 30 days prior to inclusion.
• Absence of any concomitant cancer treatment.
• Absence of any chronic treatment ( ≥3 months) with a daily corticosteroid dose is ≥20 mg / day of methylprednisolone or equivalent.
• Hematological function: neutrophils ≥1.5 x 109 / L, platelets ≥100 x 109 / l, hemoglobin ≥10 g / dl (or 6.2 mmol / l).
• Hepatic function: normal total bilirubin; AST (SGOT) and ALT (SGPT) ≤ 2.5 x ULN (LNS) of each center; alkaline phosphatase ≤ 5 x LNS.
• Renal function: serum creatinine ≤ 120 mol / l (1.4 mg / dl); if creatinine > 120 mol / l, creatinine clearance should be ≥ 60 ml / min.
• calculated creatinine clearance (Crockcroft formula) or measured ≥ 60 ml / min
• Estimated life expectancy ≥ 3 months
• Weight loss less than 10% over the last 3 months
• VHI and DHI questionary
• Quality of Life Questionnaire QLQ-C30 and QLQ-H & N35
• Patient has given its written consent before any specific procedure of the Protocol.
• Women and men of childbearing age should have accepted a medically effective contraception during the treatment period and at least 6 months after discontinuation of study treatments (Docetaxel, 5-Fluorouracil and Cisplatin. If pregnancy is declared by a patient or partner of a patient, it must be followed to know the evolution of pregnancy.
• Dynamic Vidéoscopie of deglutition

Exclusion Criteria:

• transglottic T3 with massive infiltration of hemilarynx or T4 with massive cartilaginous tumor lysis or reverse cricoarythénoïdenne region or posterior hypopharyngeal wall
• tumor requiring the completion of an immediately tracheotomy.
• Tumour available immediately to partial surgery.
• tumor requiring circular hypopharyngectomie
• N3 nodal injury
• Vaccination against yellow fever recent or anticipated
• Deficit known dihydropyrimidine dehydrogenase (DPD)
• Other malignancies within 5 years prior to randomization, with the exception of adequately treated basal skin cancer and carcinoma in situ of the cervix.
• Patients with AST or ALT> 1.5xULN associated with alkaline phosphatase > 2.5x LNS will not be eligible for testing.
• symptomatic neuropathy grade ≥2 with NCI-CTC.
• Clinical alteration of hearing function.

• Other concomitant serious medical conditions (partial list):

  • Unstable cardiac disease despite treatment.
  • Myocardial infarction within 6 months prior to trial entry.
  • Neurological or psychiatric history such as dementia, seizures;
  • Severe uncontrolled infection.
  • Significant gastrointestinal abnormalities, including those that require parenteral nutrition, active peptic ulcer disease and a history of surgical procedures affecting absorption
  • Obstructive pulmonary disease requiring hospitalization in the year before inclusion.
  • Unstable diabetes or other cons-indications to corticosteroids.
  • Significant ophthalmologic abnormality.
  • Moderate or severe eczema.
• Allergy to iodine.
• Hypersensitivity to Docetaxel, Cisplatin or at one of their excipients.
• Concomitant use of phenytoin, carbamazepine, barbiturates and rifampicin.
• Presence, selection, psychological factors, family, social or geographical may alter patient compliance with the study protocol and follow-up, a criterion of non-inclusion. These factors should be discussed with the patient before inclusion in the trial.
• Pregnant or nursing women.
• Patient (male or female) of childbearing age not taking adequate contraceptive measures.