• Area Under Plasma Concentration-time Curve From Zero to Infinity (AUC) [ Time Frame: Day 1: Pre-dose and up to 72-hour Post-dose ]
  To evaluate the relative bioavailability between the A-capsule and B-capsule formulations under both fed and fasted conditions with the ER8 capsule formulation under fasted conditions and with each other under the same food conditions.
• AUC From Time 0 to the Last Quantifiable Concentration (AUC0-t) for the Analysis of PK Parameter [ Time Frame: Day 1: Pre-dose and up to 72-hour Post-dose ]
  To evaluate the relative bioavailability between the A-capsule and B-capsule formulations under both fed and fasted conditions with the ER8 capsule formulation under fasted conditions and with each other under the same food conditions.
• Maximum Observed Plasma Concentration (Cmax) for the Analysis of PK Parameter [ Time Frame: Day 1: Pre-dose and up to 72-hour Post-dose ]
  To evaluate the relative bioavailability between the A-capsule and B-capsule formulations under both fed and fasted conditions with the ER8 capsule formulation under fasted conditions and with each other under the same food conditions.

• Area under plasma concentration-time curve from zero to infinity (AUC) for for the analysis of pharmacokinetics (PK) parameter [ Time Frame: Day 1: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 8, 10 and 12 hours post-dose; Day 2: 24 and 36 hours post-dose; Day 3: 48 hours post-dose; Day 4: 72 hours post-dose ]
  To evaluate the relative bioavailability between the A-capsule and B-capsule formulations under both fed and fasted conditions with the ER8 capsule formulation under fasted conditions and with each other under the same food conditions.
• AUC From Time 0 to the Last Quantifiable Concentration (AUC0-t) for the Analysis of PK Parameter [ Time Frame: Day 1: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 8, 10 and 12 hours post-dose; Day 2: 24 and 36 hours post-dose; Day 3: 48 hours post-dose; Day 4: 72 hours post-dose ]
  To evaluate the relative bioavailability between the A-capsule and B-capsule formulations under both fed and fasted conditions with the ER8 capsule formulation under fasted conditions and with each other under the same food conditions.
• Maximum Observed Plasma Concentration (Cmax) for the Analysis of PK Parameter [ Time Frame: Day 1: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 8, 10 and 12 hours post-dose; Day 2: 24 and 36 hours post-dose; Day 3: 48 hours post-dose; Day 4: 72 hours post-dose ]
  To evaluate the relative bioavailability between the A-capsule and B-capsule formulations under both fed and fasted conditions with the ER8 capsule formulation under fasted conditions and with each other under the same food conditions.

• AUC From Time 0 to 24 Hours Post Dose (AUC0-24) for the Analysis of PK Parameter [ Time Frame: Pre-dose and up to 24-hours Post-dose ]
  To examine the PK profiles of verinurad when administered as the 3 different capsule formulations under fasted conditions.
• Time to Reach Maximum Observed Plasma Concentration (Tmax) for the Analysis of PK Parameter [ Time Frame: Day 1: Pre-dose and up to 72-hour Post-dose ]
  To examine the PK profiles of verinurad when administered as the 3 different capsule formulations under fasted conditions.
• Half-life Associated With Terminal Slope (λz) of a Semi-logarithmic Concentration-time Curve (t½λz) for the Analysis of PK Parameter [ Time Frame: Day 1: Pre-dose and up to 72-hour Post-dose ]
  To examine the PK profiles of verinurad when administered as the 3 different capsule formulations under fasted conditions.
• Apparent Total Body Clearance of Drug From Plasma After Extravascular Administration (CL/F) for the Analysis of PK Parameter [ Time Frame: Day 1: Pre-dose and up to 72-hour Post-dose ]
  To examine the PK profiles of verinurad when administered as the 3 different capsule formulations under fasted conditions.
• Mean Residence Time of the Unchanged Drug in the Systemic Circulation From Zero to Infinity (MRT) for the Analysis of PK Parameter [ Time Frame: Day 1: Pre-dose and up to 72-hour Post-dose ]
  To examine the PK profiles of verinurad when administered as the 3 different capsule formulations under fasted conditions.
• Time of Last Quantifiable Plasma Concentration (Tlast) for the Analysis of PK Parameter [ Time Frame: Day 1: Pre-dose and up to 72-hour Post-dose ]
  To examine the PK profiles of verinurad when administered as the 3 different capsule formulations under fasted conditions.
• Volume of Distribution at Steady State (Intravenous Dosing) (Vss/F) for the Analysis of PK Parameter [ Time Frame: Day 1: Pre-dose and up to 72-hour Post-dose ]
  To examine the PK profiles of verinurad when administered as the 3 different capsule formulations under fasted conditions.
• Apparent Volume of Distribution During the Terminal Phase After Extravascular Administration (Vz/F) for the Analysis of PK Parameter [ Time Frame: Day 1: Pre-dose and up to 72-hour Post-dose ]
  To examine the PK profiles of verinurad when administered as the 3 different capsule formulations under fasted conditions.
• Number of Participants With Adverse Events (AEs) [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess AEs as variable of safety and tolerability of single doses of verinurad in healthy participants.

• AUC From Time 0 to 24 Hours Post Dose (AUC0-24) for the Analysis of PK Parameter [ Time Frame: Day 1: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 8, 10 and 12 hours post-dose; Day 2: 24 and 36 hours post-dose; Day 3: 48 hours post-dose; Day 4: 72 hours post-dose ]
  To examine the PK profiles of verinurad when administered as the 3 different capsule formulations under fasted conditions.
• Time to Reach Maximum Observed Plasma Concentration (Tmax) for the Analysis of PK Parameter [ Time Frame: Day 1: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 8, 10 and 12 hours post-dose; Day 2: 24 and 36 hours post-dose; Day 3: 48 hours post-dose; Day 4: 72 hours post-dose ]
  To examine the PK profiles of verinurad when administered as the 3 different capsule formulations under fasted conditions.
• Half-life Associated With Terminal Slope (λz) of a Semi-logarithmic Concentration-time Curve (t½λz) for the Analysis of PK Parameter [ Time Frame: Day 1: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 8, 10 and 12 hours post-dose; Day 2: 24 and 36 hours post-dose; Day 3: 48 hours post-dose; Day 4: 72 hours post-dose ]
  To examine the PK profiles of verinurad when administered as the 3 different capsule formulations under fasted conditions.
• Apparent Total Body Clearance of Drug From Plasma After Extravascular Administration (CL/F) for the Analysis of PK Parameter [ Time Frame: Day 1: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 8, 10 and 12 hours post-dose; Day 2: 24 and 36 hours post-dose; Day 3: 48 hours post-dose; Day 4: 72 hours post-dose ]
  To examine the PK profiles of verinurad when administered as the 3 different capsule formulations under fasted conditions.
• Mean Residence Time of the Unchanged Drug in the Systemic Circulation From Zero to Infinity (MRT) for the Analysis of PK Parameter [ Time Frame: Day 1: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 8, 10 and 12 hours post-dose; Day 2: 24 and 36 hours post-dose; Day 3: 48 hours post-dose; Day 4: 72 hours post-dose ]
  To examine the PK profiles of verinurad when administered as the 3 different capsule formulations under fasted conditions.
• Time of Last Quantifiable Plasma Concentration (Tlast) for the Analysis of PK Parameter [ Time Frame: Day 1: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 8, 10 and 12 hours post-dose; Day 2: 24 and 36 hours post-dose; Day 3: 48 hours post-dose; Day 4: 72 hours post-dose ]
  To examine the PK profiles of verinurad when administered as the 3 different capsule formulations under fasted conditions.
• Volume of Distribution at Steady State (Intravenous Dosing) (Vss/F) for the Analysis of PK Parameter [ Time Frame: Day 1: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 8, 10 and 12 hours post-dose; Day 2: 24 and 36 hours post-dose; Day 3: 48 hours post-dose; Day 4: 72 hours post-dose ]
  To examine the PK profiles of verinurad when administered as the 3 different capsule formulations under fasted conditions.
• Apparent Volume of Distribution During the Terminal Phase After Extravascular Administration (Vz/F) for the Analysis of PK Parameter [ Time Frame: Day 1: Pre-dose, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 8, 10 and 12 hours post-dose; Day 2: 24 and 36 hours post-dose; Day 3: 48 hours post-dose; Day 4: 72 hours post-dose ]
  To examine the PK profiles of verinurad when administered as the 3 different capsule formulations under fasted conditions.
• Number of Participants With Adverse Events (AEs) [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess AEs as variable of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal blood pressure (bothsystolic and diastolic blood pressure) [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To measure BP as variable of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal pulse rate [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To measure pulse rate as variable of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal 12-lead Electrocardiograms (ECG) [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the safety and tolerability of single doses of verinurad in healthy participants. 12-lead safety ECG will be obtained after the participant rested in the supine position for at least 10 minutes using the sites own ECG machines. The Principal Investigator (PI) will judge the overall interpretation as normal or abnormal and this evaluation will be reported in ClinBase. If abnormal, it will be further documented as to whether or not the abnormality is clinically significant by the PI.
• Number of participants with abnormal physical examination findings [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess any clinically significant abnormal physical examination findings as a variable of safety and tolerability of single doses of verinurad in healthy participants. The complete physical examinations will include an assessment of the general appearance, respiratory, cardiovascular, abdomen, skin, head, and neck (including ears, eyes, nose, and throat), lymph nodes, thyroid, musculoskeletal and neurological systems. The brief physical examinations will include an assessment of the general appearance, skin, abdomen, cardiovascular system and respiratory.
• Number of participants with abnormal laboratory assessments: Hematology-White blood cell (WBC) count [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the white blood cell count as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participnats with abnormal laboratory assessments: Hematology- Red blood cell (RBC) count [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the red blood cell count as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of paticipants with abnormal laboratory assessments: Hematology -Hemoglobin (Hb) [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the Hb as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Hematology Hematocrit (HCT) and Reticulocyte absolute count [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the HCT and reticulocyte absolute count as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Hematology-Mean corpuscular hemoglobin (MCH) [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the MCH as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Hematology-Mean corpuscular volume (MCV) [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the MCV as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Hematology-Mean corpuscular hemoglobin concentration (MCHC) [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the MCHC as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Hematology-Neutrophils absolute count [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the neutrophils absolute count as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Hematology-Lymphocytes absolute count [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the Lymphocytes absolute count as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Hematology-Monocytes absolute count [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the Monocytes absolute count as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Hematology-Eosinophils absolute count [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the Eosinophils absolute count as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Hematology-Basophils absolute count [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the Basophils absolute count as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Hematology-Platelets count [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the platelets count as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Serum Clinical chemistry - Calcium, potassium, phosphate and sodium [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the serum calcium, potassium, phosphate and sodium level as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Serum Clinical chemistry - Liver enzymes [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the serum Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), Aspartate aminotransferase (AST) and Gamma glutamyl transpeptidase (GGT) level as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Serum Clinical chemistry -Albumin [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the albumin level as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Serum Clinical chemistry - C-reactive protein (CRP) [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the CRP level as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Serum Clinical chemistry - Creatinine [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the creatinine level as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Serum Clinical chemistry - Glucose (fasting) [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the fasting glucose level as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Serum Clinical chemistry - Uric acid [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the uric acid level as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Serum Clinical chemistry - Total Bilirubin (TBL) [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the TBL level as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Serum Clinical chemistry - blood urea nitrogen (BUN) [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the urea level as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Serum Clinical chemistry - Follicle stimulating hormone (FSH) [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the FSH level as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Serum Clinical chemistry - Unconjugated bilirubin [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the unconjugated bilirubin level as variables of safety and tolerability of single doses of verinurad in healthy participants.
• Number of participants with abnormal laboratory assessments: Clinical Urinalysis - Protein [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the urine protein level as variables of safety and tolerability of single doses of verinurad in healthy participants. Upon a positive urine test protein, the Investigator may require further urine analysis, such as flow cytometry.
• Number of participants with abnormal laboratory assessments: Clinical Urinalysis - Blood [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the urine blood level as variables of safety and tolerability of single doses of verinurad in healthy participants. Upon a positive urine test from blood, the Investigator may require further urine analysis, such as flow cytometry.
• Number of participants with abnormal laboratory assessments: Clinical Urinalysis - Glucose [ Time Frame: From screening (Day -28 to Day -2) till follow-up visit (7 to 14 days post-final dose) ]
  To assess the urine glucose level as variables of safety and tolerability of single doses of verinurad in healthy participants.

• Drug: Verinurad ER8 capsule formulation (fasted)
  Each participant will receive single-dose treatment of 12 mg verinurad ER8 capsule with 240 mL water, following an overnight fast of at least 10 hours.
• Drug: Verinurad A-capsule formulation (fasted)
  Each participant will receive single-dose treatment of 12 mg verinurad A-capsule with 240 mL water, following an overnight fast of at least 10 hours.
• Drug: Verinurad A-capsule formulation (fed)
  Each participant will receive single dose treatment of 12 mg verinurad A-capsule with 240 mL water, following a high-fat, high-calorie breakfast (after the overnight fast).
• Drug: Verinurad B-capsule formulation (fasted)
  Each participant will receive single-dose treatment of 12 mg verinurad B-capsule with 240 mL water, following an overnight fast of at least 10 hours.
• Drug: Verinurad B-capsule formulation (fed)
  Each participant will receive single dose treatment of 12 mg verinurad B-capsule with 240 mL water, following a high-fat, high-calorie breakfast (after the overnight fast).

• Experimental: Treatment 1
  During this treatment period, healthy participants will receive 1 x 12 mg verinurad ER8 capsule formulation in fasted state.
  Intervention: Drug: Verinurad ER8 capsule formulation (fasted)
• Experimental: Treatment 2
  During this treatment period, healthy participants will receive 2 x 6 mg verinurad A-capsule formulation in fasted state.
  Intervention: Drug: Verinurad A-capsule formulation (fasted)
• Experimental: Treatment 3
  During this treatment period, healthy participants will receive 2 x 6 mg verinurad A-capsule formulation in fed state.
  Intervention: Drug: Verinurad A-capsule formulation (fed)
• Experimental: Treatment 4
  During this treatment period, healthy participants will receive 2 x 6 mg verinurad B-capsule formulation in fasted state.
  Intervention: Drug: Verinurad B-capsule formulation (fasted)
• Experimental: Treatment 5
  During this treatment period, healthy participants will receive 2 x 6 mg verinurad B-capsule formulation in fed state.
  Intervention: Drug: Verinurad B-capsule formulation (fed)

Inclusion Criteria:

1. Provision of signed and dated, written informed consent prior to any study specific procedures.
2. Healthy male and female participants aged 18 to 50 years with suitable veins for cannulation or repeated venepuncture.
3. Have a body mass index (BMI) between 18 and 30 kg/m2 and weigh at least 50 kg and no more than 100 kg.
4. Females must have a negative pregnancy test at screening and on admission to the unit and must be:

(1) not pregnant or currently lactating or breastfeeding. (2) of non-childbearing potential, confirmed at screening by fulfilling one of the following criteria: (i) postmenopausal defined as amenorrhoea for at least 12 months or more following cessation of all exogenous hormonal treatments and FSH levels in the postmenopausal range (FSH levels > 40 IU/mL).

(ii) documentation of irreversible surgical sterilization by hysterectomy, bilateral oophorectomy or bilateral salpingectomy but not tubal ligation.

(3) OR if of childbearing potential must be willing to use an acceptable method of contraception to avoid pregnancy for the entire study period.

Exclusion Criteria:

1. History of gout or any clinically significant disease or disorder which, in the opinion of the Principal Investigator (PI), may either put the volunteer at risk because of participation in the study, or influence the results or the volunteer's ability to participate in the study.
2. Any clinically important illness, medical/surgical procedure or trauma within 4 weeks of the first administration of verinurad.
3. History or presence of gastrointestinal (GI), hepatic or renal disease, or any other condition known to interfere with absorption, distribution, metabolism, or excretion of drugs.
4. Any clinically important abnormalities in clinical chemistry, haematology or urinalysis results as judged by the Investigator at screening and first admission, including: (1) Alanine aminotransferase (ALT) > 1.5 x upper limit of normal (ULN), (2) Aspartate aminotransferase (AST) > 1.5 x ULN, (3) Bilirubin (total) > 1.5 x ULN, (4) Gamma glutamyl transpeptidase (GGT) > 1.5 x ULN. (5) If any of these tests are out-of-range, the tests can be repeated once.
5. Any clinically significant abnormal findings in vital signs at the Screening Visit and/or admission to the Clinical Unit, including, but not limited to, any of the following:

(1) Heart rate (resting, supine) < 50 beats per minute (bpm) or > 85 bpm, (2) Systolic BP < 90 mmHg or > 140 mmHg and/or diastolic BP < 50 mmHg or > 90 mmHg sustained for > 10 min while resting in a supine position.

6. Any clinically significant abnormalities on 12-lead Electrocardiogram (ECG) at the Screening Visit, including, but not limited to any of the following:

1. ECG interval measured from the onset of the QRS complex to the end of the T wave (QT) interval corrected for heart rate using Fridericia's formula (QTcF) > 450 ms or < 340 ms or family history of long QT syndrome,
2. Any significant arrhythmia,
3. Conduction abnormalities:
4. Clinically significant PR (PQ) interval prolongation (> 240 ms); intermittent second or third degree atrioventricular (AV) block, or AV dissociation,
5. Complete bundle branch block and/or QRS duration > 120 ms. 7. Any positive result at the Screening Visit for serum hepatitis B surface antigen or antiHBc antibody, hepatitis C antibody, and human immunodeficiency virus (HIV) antibody.

8. Suspicion or known Gilbert's and/or Lesch-Nyhan syndrome. 9. Known or suspected history of alcohol or drug abuse or excessive intake of alcohol as judged by the PI. Excessive intake of alcohol defined as the regular consumption of more than 24 g of alcohol per day for men or 12 g of alcohol per day for women.

10. Has received another new chemical entity (defined as a compound which has not been approved for marketing in the US) within 30 days or at least 5 half-lives (whichever is longer) of the first administration of verinurad in this study.

11. Participants who have previously received verinurad. 12. Plasma donation within 1 month of screening or any blood donation/loss of more than 500 mL during the 3 months prior to the Screening Visit.

13. Participants who are pregnant, lactating or planning to become pregnant. 14. History of severe allergy/hypersensitivity or ongoing clinically relevant allergy/hypersensitivity, as judged by the PI or history of hypersensitivity to drugs with a similar chemical structure or class to verinurad.

15. Current smokers or those who have smoked or used nicotine products (including e-cigarettes) within the 3 months prior to screening.

16. Excessive intake of caffeine-containing drinks or food (e.g., coffee, tea, chocolate) as judged by the PI. Excessive intake of caffeine defined as regular consumption of more than 600 mg of caffeine per day (e.g., > 5 cups of coffee) or would likely be unable to refrain from the use of caffeine containing beverages during confinement at the investigational site.

17. Positive screen for drugs of abuse or cotinine (nicotine) at the Screening Visit or positive screen for alcohol, drugs of abuse and cotinine on each admission to the study centre.

18. Use of drugs with enzyme-inducing properties such as St John's Wort within 3 weeks prior to the first administration of verinurad.

19. Use of any prescribed or non-prescribed medication including antacids, analgesics (other than paracetamol/acetaminophen), herbal remedies, megadose vitamins (intake of 20 to 600 times the recommended daily dose) and minerals during the 2 weeks prior to the first administration of verinurad or longer if the medication has a long half-life. The use of hormonal contraception therapy and hormonal replacement therapy for females are permitted.

20. Any AstraZeneca, PAREXEL or study site employee or their close relatives. 21. Participants who cannot communicate reliably with the PI and/or is not able to read, speak and understand the German language.

22. Judgment by the PI that the participant should not participate in the study if they have any ongoing or recent (i.e., during the screening period) minor medical complaints that may interfere with the interpretation of study data or are considered unlikely to comply with study procedures, restrictions, and requirements.

23. Vulnerable participants, e.g., kept in detention, protected adults under guardianship, trusteeship, or committed to an institution by governmental or juridical order.

24. Participants with any special dietary restrictions such as participants that are lactose intolerant or are vegetarians/vegans.