• Change on Gross Motor Function (GMFM-66) [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up. ]
  Developed to assess the changes in gross motor function of children with cerebral palsy (scored in percentage), observed over time or after intervention for the second randomized controlled trial (RCT2)
• Change on Manual Ability (Assisting Hand Assessment (AHA)) [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  Developed to observe the efficacy of the assisting hand use, in children with unilateral cerebral palsy (scored in percentage), during bimanual activities for the first randomized controlled trial (RCT1)

• Change on Gross Motor Function (GMFM-66) [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up. ]
  Developed to assess the changes in gross motor function of children with cerebral palsy (scored in percentage), observed over time or after intervention for the RCT2
• Change on Manual Ability (Assisting Hand Assessment (AHA)) [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  Developed to observe the efficacy of the assisting hand use, in children with unilateral cerebral palsy (scored in percentage), during bimanual activities for the RCT1

• Melbourne 2 Assessment (MA2) [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  assess the unilateral performance of the upper extremities, quantifying the dexterity, fluency, accuracy and range of movement during several tasks of reaching and manipulation
• Inhibitory control task [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  Measures the inhibition of a motor answer. It's assessed by asking the child not to reach for a toy previously showed to play with. The maximum waiting time is 30 seconds.
• Working memory task [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  Measures the capacity to retain visual information in use, in a short period of time. It's assessed by hiding a toy in front of the child and asking him/her to find it from 4 possibilities.
• Visuo-spatial attention assessment [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  Through different simple tasks, measures the visual field, the visuo-motor coordination, the orientation of attention in the space and the eye pursuit.
• Semmes-Weinstein monofilaments [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  Evaluates the pressure threshold or the response to a touching sensation of the filament. It is quantified using a numerical grading ranging from high pression/clear touching sensation to a slight pression/slight touching sensation.
• Pressure Threshold [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  The superior pressure threshold will be determined at the moment of any visible change in the child's reaction to the pression made by the algometer.
• Activlim-CP questionnaire [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  This parent's filled questionnaire measures a patient's ability to perform daily activities requiring the use of the upper and/or the lower extremities through 43 items specific to patients with cerebral palsy. It ranges from - 7 to +7 logits (higher score means better performance).
• Pediatric Evaluation of Disability Inventory questionnaire (PEDI) [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  This parent's filled questionnaire measures the performance of the child in the daily life activities and movement domains, focusing on the capacity of upper extremities and lower extremities during this activities. It ranges from 0 to 100% (higher score means better performance).
• Young children's participation and environment measure (YC-PEM) [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  Based in different children's activities, this parent's filled questionnaire evaluates the level of participation and the quality of the environment in which these activities take place. For each type of activity, caregivers assess 3 dimensions of the child's participation: frequency (8-point scale; 0-7), level of involvement (5-point scale; 1-5), caregiver's percent desire for change (2-points level (y/n) transformed in percentage; 0-100) and perceived impact of environmental support (3-point scale transformed in percentage; 0-100). A software calculates the total score with a maximum of 212 (higher score means better performance).
• Measure of Processes of Care (MPOC-20) [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  Assesses the parents' perceptions of the care they and their children receive from children's rehabilitation treatment centres. Using a 8-point response scale, parents answer to 20 questions, indicating to what extent they have experienced the events or the situations described. A score of 7 means that they have experienced this aspect to a very great extent, or most of the time. A score of 1 means that they have not experienced this aspect at all. A score of 0 means that the question does not apply to them. There is no total score. However, because the statements are positively worded, higher total scores indicates that needs of the parents are being met to a great extent.
• Canadian Occupational Performance Measure (COPM) [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  This is an interview-setting designed to capture a patient's self-perception of performance and satisfaction of it in everyday activities, observed over time. During the interview, parents set up 5 activities considered difficult in daily life. These are then assessed, in a 1 to 10 scale, regarding the child's self-perception of performance and satisfaction of it. The total score is the average of the scores for perception and satisfaction separately (score from 1 to 10; higher score means better performance/satisfaction)
• 3D T1-weighted structural imaging (T1) [ Time Frame: pre-camp, 3 months follow-up ]
  This sequence allows to measure changes in gray matter (cortical thickness)
• Changes on the Fractional Anisotropy (Diffusion tensor imaging (DTI)) [ Time Frame: pre-camp, 3 months follow-up ]
  This sequence allows to measure changes in the fractional anisotropy (FA) on the white matter tracts. FA is a scalar value (no unit) between zero and one that describes the degree of anisotropy of white matter water molecules.
• Changes on the Mean Diffusivity (Diffusion tensor imaging (DTI)) [ Time Frame: pre-camp, 3 months follow-up ]
  This sequence allows to measure the mean changes in the diffusivity (MD). MD is a scalar value (no unit) between zero and one that describes the degree of molecular diffusion.
• Changes on resting state functional connectivity (RS) [ Time Frame: pre-camp, 3 months follow-up ]
  Resting-state functional magnetic resonane imaging (rs-fMRI) evaluates the regional interactions that occur during the resting or task-negative state. The magnitud of the brain activation during rs-fMRI will be assessed
• Changes on spatial parameters of the gait (Kinematics assessments) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure the stride length (meters), step length (meters) and step width (meters).
• Changes on temporal parameters of the gait (Cycle time) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure cycle of gait time (seconds).
• Changes on temporal parameters of the gait (Stance time) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure the stance time (percentage of total gait cycle).
• Changes on temporal parameters of the gait (Swing time) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure the swing time (percentage of total gait cycle).
• Changes on temporal parameters of the gait (Stride) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure the gait cadence (stride per minute).
• Changes on temporal parameters of the gait (Velocity) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure the gait velocity (meter/second)
• Changes on temporal parameters of the gait (Acceleration) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure the gait acceleration (meters/second^2)
• Changes on spatial parameters of the upper extremity (Straightness) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure the straightness (percentage of upper extremity trajectory during a reaching task).
• Changes on spatial parameters of the upper extremity (Smoothness) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure the smoothness (variability of the movement during a reaching task)
• Changes on temporal parameters of the upper extremity (Kinematics assessments) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure the time from onset to end of the task (seconds). the task consist in a reaching task.
• Quantification of physical activity [ Time Frame: 5 hours during 5 consecutive days ]
  With a movement sensor on each wrist, the percentage of total time spent in movement (i.e. crawling, walking and running) is measured. Calculated in terms of the changes in the acceleration (m/s^2). These measurements will be performed during therapy in 5 consecutive days for the HABIT-ILE group and during a regular week for the Usual Care group.

• Melbourne 2 Assessment (MA2) [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  assess the unilateral performance of the upper extremities, quantifying the dexterity, fluency, accuracy and range of movement during several tasks of reaching and manipulation
• Inhibitory control task [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  Measures the inhibition of a motor answer. It's assessed by asking the child not to reach for a toy previously showed to play with. The maximum waiting time is 30 seconds.
• Working memory task [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  Measures the capacity to retain visual information in use, in a short period of time. It's assessed by hiding a toy in front of the child and asking him/her to find it from 4 possibilities.
• Visuo-spatial attention assessment [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  Through different simple tasks, measures the visual field, the visuo-motor coordination, the orientation of attention in the space and the eye pursuit.
• Semmes-Weinstein monofilaments [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  Evaluates the pressure threshold or the response to a touching sensation of the filament. It is quantified using a numerical grading ranging from high pression/clear touching sensation to a slight pression/slight touching sensation.
• Pressure Threshold [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  The superior pressure threshold will be determined at the moment of any visible change in the child's reaction to the pression made by the algometer.
• Activlim-CP questionnaire [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  Measures performance of the child in daily life activities focusing on upper and lower extremities.
• Pediatric Evaluation of Disability Inventory questionnaire (PEDI) [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  Measures the performance of the child in the daily life activities and movement domains, focusing on the capacity of upper extremities and lower extremities during this activities.
• Young children's participation and environment measure (YC-PEM) [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  Based in different children's activities, this questionnaire evaluates the level of participation and the quality of the environment in which these activities take place.
• Measure of Processes of Care (MPOC) [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  Assesses the parents' perceptions of the care they and their children receive from children's rehabilitation treatment centres.
• Canadian Occupational Performance Measure (COPM) [ Time Frame: pre-camp, two weeks post-camp, 3 months follow-up ]
  This is an interview-setting designed to capture a patient's self-perception of performance and satisfaction of it in everyday activities, observed over time.
• 3D T1-weighted structural imaging (T1) [ Time Frame: pre-camp, 3 months follow-up ]
  This sequence allows to measure changes in gray matter (cortical thickness)
• Changes on the Fractional Anisotropy (Diffusion tensor imaging (DTI)) [ Time Frame: pre-camp, 3 months follow-up ]
  This sequence allows to measure changes in the fractional anisotropy (FA) on the white matter tracts. FA is a scalar value (no unit) between zero and one that describes the degree of anisotropy of white matter water molecules.
• Changes on the Mean Diffusivity (Diffusion tensor imaging (DTI)) [ Time Frame: pre-camp, 3 months follow-up ]
  This sequence allows to measure the mean changes in the diffusivity (MD). MD is a scalar value (no unit) between zero and one that describes the degree of molecular diffusion.
• Functional resting state (RS) [ Time Frame: pre-camp, 3 months follow-up ]
  This sequence allows to evaluates the regional interactions that occur in a resting or task-negative state.
• Changes on spatial parameters of the gait (Kinematics assessments) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure the stride length (meters), step length (meters) and step width (meters).
• Changes on temporal parameters of the gait (Cycle time) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure cycle of gait time (seconds).
• Changes on temporal parameters of the gait (Stance time) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure the stance time (percentage of total gait cycle).
• Changes on temporal parameters of the gait (Swing time) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure the swing time (percentage of total gait cycle).
• Changes on temporal parameters of the gait (Stride) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure the gait cadence (stride per minute).
• Changes on temporal parameters of the gait (Velocity) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure the gait velocity (meter/second)
• Changes on temporal parameters of the gait (Acceleration) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure the gait acceleration (meters/second^2)
• Changes on spatial parameters of the upper extremity (Straightness) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure the straightness (percentage of upper extremity trajectory during a reaching task).
• Changes on spatial parameters of the upper extremity (Smoothness) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure the smoothness (variability of the movement during a reaching task)
• Changes on temporal parameters of the upper extremity (Kinematics assessments) [ Time Frame: pre-camp, 3 months follow-up ]
  Through a 3D motion system, we measure the time from onset to end of the task (seconds). the task consist in a reaching task.
• Quantification of physical activity [ Time Frame: 5 hours during 5 consecutive days ]
  With a movement sensor on each wrist, the percentage of total time spent in movement (i.e. crawling, walking and running) is measured. Calculated in terms of the changes in the acceleration (m/s^2). These measurements will be performed during therapy in 5 consecutive days for the HABIT-ILE group and during a regular week for the Usual Care group.

• Behavioral: HABIT-ILE
  Early Hand and arm bimanual intensive therapy including lower extremities
• Behavioral: Usual Care
  Usual customary care

• Experimental: HABIT-ILE
  Early HABIT-ILE (Hand and arm bimanual intensive therapy including lower extremities) will be applied over 2 weeks.
  Intervention: Behavioral: HABIT-ILE
• Active Comparator: Usual Care
  A two weeks period of usual customary care
  Intervention: Behavioral: Usual Care

Inclusion Criteria:

• children with unilateral or bilateral cerebral palsy (spastic or dyskinetic)
• age 1 to 4 years inclusive (corrected age if preterm birth)
• ability to follow instructions and complete testing according to the age.

Exclusion Criteria:

• active seizure
• programmed botulinum toxin or orthopedic surgery in the 6 months previous to the intervention, during intervention period or 3months after the intervention time
• severe visual impairments
• severe cognitive impairments
• contraindications to perform MRI assessments (Metal implants, etc.)

• University Hospital, Brest
• University of Pisa
• University Hospital, Angers
• University of Lausanne Hospitals
• University of the Balearic Islands
• Fondation Paralysie Cérébrale