• Mean finger ischemia time [ Time Frame: 2 year ]
  Mean finger ischemia time of five fingers during cooling and recovery, as assessed by routine cooling and recovery photo-electric plethysmography (PPG) after 2 years of follow-up, in minutes
• Raynaud Condition Score [ Time Frame: 1,2,3,4,5 years ]
  Mean Raynaud condition score (0-100) over a period 14 days
• Number of attacks [ Time Frame: 1,2,3,4,5 years ]
  Mean number of RP attacks per day over a period of 14 days
• Duration of attacks [ Time Frame: 1,2,3,4,5 years ]
  Mean duration of RP attacks per day over a period of 14 days in minutes
• SF-36 [ Time Frame: 1,2,3,4,5 years ]
  Health-related quality of life short form (SF)-36 score of 100-0
• HAQ [ Time Frame: 1,2,3,4,5 years ]
  (Dutch) health assessment questionnaire (HAQ) score of 0-3
• Capillary density [ Time Frame: 2 and 5 years ]
  Mean number of capillaries per finger of 8 fingers per 3mm
• Number of dilated capillaries [ Time Frame: 2 and 5 year ]
  Mean number of dilated capillaries per finger (apex width >20µm, <50µm) of 8 fingers per 3mm
• Number of giant capillaries [ Time Frame: 2 and 5 year ]
  Mean number of giant capillaries per finger (apex width >50µm) of 8 fingers per 3mm
• Capillaroscopic pattern [ Time Frame: 2 and 5 year ]
  Pattern of nailfold capillaries (normal, non-specific, early, active or late)
• Pulse wave velocity brachial-radial [ Time Frame: 2 and 5 years ]
  Pulse wave velocity in m/s of brachial-radial trajectory
• Systolic blood pressure [ Time Frame: 2 and 5 years ]
  Brachial systolic blood pressure in mmHg
• Diastolic blood pressure [ Time Frame: 2 and 5 years ]
  Brachial diastolic blood pressure in mmHg
• Mean finger blood pressure [ Time Frame: 2 and 5 years ]
  Mean finger blood pressure in mmHg of eight fingers
• Pulse wave velocity brachial-ulnar [ Time Frame: 2 and 5 years ]
  Pulse wave velocity in m/s of brachial-ulnar trajectory
• Digital ulcers [ Time Frame: 1,2,3,4,5 years ]
  Incidence of digital ulcers (yes/no)
• Compensatory sweating [ Time Frame: 1,2,3,4,5 years ]
  Compensatory sweating (yes/no)
• Wound infection or other adverse events [ Time Frame: 2 weeks, 1,2,3,4,5 years ]
  Occurrence of wound infection or other adverse events potentially related to SPTS

Background: Raynaud's phenomenon is a vasospasm of the extremities, leading to extensive discomfort in daily life and potentially severe ischemia. Some patients are resistant to conventional vasodilatory drug treatment. In the University Medical Center Groningen, single-port thoracoscopic sympathicotomy (SPTS) was developed. This is a new minimally invasive endoscopic technique, extensively limiting surgical burden. In many hospitals in the Netherlands, this operation is sometimes performed on patients with Raynaud's phenomenon. However, the techniques used are more invasive than the SPTS technique. Furthermore, studies on sympathectomy and sympathicotomy in Raynaud's are limited and encompass obsolete more invasive techniques. Also, it is unclear which patients would benefit the most and for how long and in which percentage of patients treatment effects persist over time. In a recent study on the new SPTS technique, it was found that one month after the procedure, the Raynaud's attacks were substantially reduced and the hand perfusion increased on the operated side. Based on these short term effects and previously reported broad experience with this technique for other indications, it is possible to offer this option to a broader range of patients with Raynaud's as a reasonable and safe treatment option. However, whether the effects persist on the long-term needs to be established.

Main research question: The aim of the study is to assess the 5 year efficacy and outcome in patients with primary and secondary Raynaud's phenomenon in whom SPTS has been performed.

Design (including population, confounders/outcomes): Patients with Raynaud's, who will undergo SPTS in patient care setting, will be included. Data from the patient file will be collected, including vascular measurements to assess hand perfusion, a Raynaud diary (Raynaud condition score, duration and frequency of the attacks), quality of life questionnaires, and adverse events.

• Full responders
  Full responders: no signs or symptoms of Raynaud's phenomenon (RP) in Raynaud condition score, no RP during cooling-recovery experiment.
  Intervention: Procedure: Single-port thoracoscopic sympathicotomy (patient care)
• Partial responders
  Partial responders: at least 25% reduction in Raynaud condition score and finger ischemia time during cooling and recovery.
  Intervention: Procedure: Single-port thoracoscopic sympathicotomy (patient care)
• Non-responders
  Non-responders: no or less than 25% reduction in Raynaud condition score and/or finger ischemia time during cooling and recovery.
  Intervention: Procedure: Single-port thoracoscopic sympathicotomy (patient care)

Inclusion Criteria:

• Raynaud's phenomenon of the hands
• Scheduled SPTS as treatment for RP
• Age ≥ 16 years

Exclusion Criteria:

• SPTS for other indications than RP