免费获得国外相关药品，最快 1 个工作日回馈药物信息
出境医 / 临床实验 / Mindreading in Adults With Autism Spectrum Disorder
Mindreading in Adults With Autism Spectrum Disorder
Study Description
Brief Summary:
This study aims to investigate the ability of reading emotions by the Eyes task in adults with ASD, and examine the gazing pattern and frontal activation during the task. We plan to recruit 50 adults with ASD and 50 typically-developing adults. Eye-tracking and frontal activation (measured by functional near-infrared spectroscopy) will be examined during the Eyes task.
| Condition or disease | Intervention/treatment |
|---|---|
| Autism Spectrum Disorder | Other: no intervention |
Detailed Description:
Autism spectrum disorder (ASD) is a clinical syndrome characterized by mindreading deficits, or Theory of Mind deficits. The Reading the Mind in the Eyes task (abbreviated as the Eyes task) was developed to assess the mindreading deficits as a hallmark of social deficits of ASD. This study aims to investigate the ability of reading emotions by the Eyes task in adults with ASD, and examine the gazing pattern and frontal activation during the task. We plan to recruit 50 adults with ASD and 50 typically-developing adults. All the participants will complete clinical measures and the Eyes task. Eye-tracking and frontal activation (measured by functional near-infrared spectroscopy) will be examined during the Eyes task.
Study Design
| Study Type : | Observational |
| Estimated Enrollment : | 60 participants |
| Observational Model: | Case-Control |
| Time Perspective: | Cross-Sectional |
| Official Title: | Mindreading in Adults With Autism Spectrum Disorder |
| Actual Study Start Date : | January 8, 2019 |
| Estimated Primary Completion Date : | November 2019 |
| Estimated Study Completion Date : | November 2019 |
Arms and Interventions
| Group/Cohort | Intervention/treatment |
|---|---|
|
ASD Group
Autism spectrum disorder participants, no intervention
|
Other: no intervention
no intervention
|
|
TD Group
Typically developmental controls,no intervention
|
Other: no intervention
no intervention
|
Outcome Measures
Primary Outcome Measures :
- eye tracking indicators [ Time Frame: 30 min ]eye tracking indicators
Eligibility Criteria
| Ages Eligible for Study: | 20 Years to 50 Years (Adult) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Study Population
The 30 adults with ASD will be recruited from Adult ASD clinics in Department of Psychiatry, National Taiwan University Hospital.
Criteria
Inclusion Criteria:
- Adult aged between 20 and 50 years who had a diagnosis of ASD based on DSM-5.
- Had a full-scale IQ > 70 on WAIS-IV.
Exclusion Criteria:
- A history of major mental illness (e.g., bipolar affective disorder, schizophrenia) or neurological diseases.
- Visual impairment and that would preclude participation.
Contacts and Locations
Contacts
| Contact: Yi Ling Chien, M.D., Ph.D. | 886-2-2312-3456 ext 66013 | ylchien@hotmail.com |
Locations
| Taiwan | |
| National Taiwan University Hospital | Recruiting |
| Taipei, Taiwan | |
| Contact: Yi Ling Chien, M.D., Ph.D. 886-2-2312-3456 ext 66013 ylchien@hotmail.com | |
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
| Principal Investigator: | Yi Ling Chien, M.D., Ph.D. | National Taiwan University Hospital |
| Tracking Information | |||||
|---|---|---|---|---|---|
| First Submitted Date | July 4, 2019 | ||||
| First Posted Date | July 8, 2019 | ||||
| Last Update Posted Date | July 8, 2019 | ||||
| Actual Study Start Date | January 8, 2019 | ||||
| Estimated Primary Completion Date | November 2019 (Final data collection date for primary outcome measure) | ||||
| Current Primary Outcome Measures |
eye tracking indicators [ Time Frame: 30 min ] eye tracking indicators
|
||||
| Original Primary Outcome Measures | Same as current | ||||
| Change History | No Changes Posted | ||||
| Current Secondary Outcome Measures | Not Provided | ||||
| Original Secondary Outcome Measures | Not Provided | ||||
| Current Other Pre-specified Outcome Measures | Not Provided | ||||
| Original Other Pre-specified Outcome Measures | Not Provided | ||||
| Descriptive Information | |||||
| Brief Title | Mindreading in Adults With Autism Spectrum Disorder | ||||
| Official Title | Mindreading in Adults With Autism Spectrum Disorder | ||||
| Brief Summary | This study aims to investigate the ability of reading emotions by the Eyes task in adults with ASD, and examine the gazing pattern and frontal activation during the task. We plan to recruit 50 adults with ASD and 50 typically-developing adults. Eye-tracking and frontal activation (measured by functional near-infrared spectroscopy) will be examined during the Eyes task. | ||||
| Detailed Description | Autism spectrum disorder (ASD) is a clinical syndrome characterized by mindreading deficits, or Theory of Mind deficits. The Reading the Mind in the Eyes task (abbreviated as the Eyes task) was developed to assess the mindreading deficits as a hallmark of social deficits of ASD. This study aims to investigate the ability of reading emotions by the Eyes task in adults with ASD, and examine the gazing pattern and frontal activation during the task. We plan to recruit 50 adults with ASD and 50 typically-developing adults. All the participants will complete clinical measures and the Eyes task. Eye-tracking and frontal activation (measured by functional near-infrared spectroscopy) will be examined during the Eyes task. | ||||
| Study Type | Observational | ||||
| Study Design | Observational Model: Case-Control Time Perspective: Cross-Sectional |
||||
| Target Follow-Up Duration | Not Provided | ||||
| Biospecimen | Not Provided | ||||
| Sampling Method | Non-Probability Sample | ||||
| Study Population | The 30 adults with ASD will be recruited from Adult ASD clinics in Department of Psychiatry, National Taiwan University Hospital. | ||||
| Condition | Autism Spectrum Disorder | ||||
| Intervention | Other: no intervention
no intervention
|
||||
| Study Groups/Cohorts |
|
||||
| Publications * | Not Provided | ||||
|
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline. |
|||||
| Recruitment Information | |||||
| Recruitment Status | Unknown status | ||||
| Estimated Enrollment |
60 | ||||
| Original Estimated Enrollment | Same as current | ||||
| Estimated Study Completion Date | November 2019 | ||||
| Estimated Primary Completion Date | November 2019 (Final data collection date for primary outcome measure) | ||||
| Eligibility Criteria |
Inclusion Criteria:
Exclusion Criteria:
|
||||
| Sex/Gender |
|
||||
| Ages | 20 Years to 50 Years (Adult) | ||||
| Accepts Healthy Volunteers | Yes | ||||
| Contacts | Contact information is only displayed when the study is recruiting subjects | ||||
| Listed Location Countries | Taiwan | ||||
| Removed Location Countries | |||||
| Administrative Information | |||||
| NCT Number | NCT04010409 | ||||
| Other Study ID Numbers | 201809069RINA | ||||
| Has Data Monitoring Committee | No | ||||
| U.S. FDA-regulated Product |
|
||||
| IPD Sharing Statement | Not Provided | ||||
| Responsible Party | National Taiwan University Hospital | ||||
| Study Sponsor | National Taiwan University Hospital | ||||
| Collaborators | Not Provided | ||||
| Investigators |
|
||||
| PRS Account | National Taiwan University Hospital | ||||
| Verification Date | December 2018 | ||||
