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出境医 / 临床实验 / Comparison of the Severity of Coronary Atherosclerosis With Tissue Compliance in Patients Within First Degree Relatives
Comparison of the Severity of Coronary Atherosclerosis With Tissue Compliance in Patients Within First Degree Relatives
Study Description
Brief Summary:
This study research the similarity of coronary artery lesions according to HLA tissue compatibility in fisrt degree relatives of the patients who just admitted clinic as Acute coronary syndrome and underwent angiyography before .
| Condition or disease | Intervention/treatment |
|---|---|
| Coronary Artery Disease With Myocardial Infarction | Diagnostic Test: there is not any intervention procedure |
Detailed Description:
Coronary artery disease (CAD), which is mainly caused by atherosclerosis, is the most prevalent illness and the leading cause of death worldwide. Increasing evidence suggests that inflammation plays a primordial role in atherogenesis and is closely associated with the major histocompatibility complex (MHC) (human leukocyte antigen [HLA] in humans) molecules. HLA genes are located in 6p21.3, the proteins encoded by these HLA genes have a major role to play in antigen presentation and inflammatory pathways. HLA involvement in inflammation is mainly associated with the HLA-dependent activation of T cells. studies reported that the susceptibility to CAD is related with the polymorphisms in HLA-DRB1. The above evidence indicates that the polymorphisms in HLA class II are associated with the risk of CAD . This study research investigate three objects , firstly what is the similarity of the coronary artery lesions according to the compatability of HLA alleles between the first degree relatives who went angiography before , secondly is there any relation between HLA subtype allels and the coronary artery (RCA ?LAD ? ,CX? and can such a relation be responsible from the lesions in this artery ,finally is there any relation between HLA subtypes and turkish race coronary artery disease
Study Design
| Study Type : | Observational |
| Estimated Enrollment : | 60 participants |
| Observational Model: | Family-Based |
| Time Perspective: | Other |
| Official Title: | Comparison of the Severity and Prevalence of Coronary Atherosclerosis With Tissue Compliance (HLA Similarity ) in Patients Within First Degree Relatives |
| Estimated Study Start Date : | September 18, 2020 |
| Estimated Primary Completion Date : | December 7, 2020 |
| Estimated Study Completion Date : | January 1, 2021 |
Arms and Interventions
Outcome Measures
Primary Outcome Measures :
- relation between HLA subgroups and severity and prevelance of coronary artery lesions [ Time Frame: 20 MAY 2019 - 30 MAY 2019 ]the hla similarity of two sibling patient %80 and the military syntax score %97,7
Biospecimen Retention: Samples With DNA
blood sample
Eligibility Criteria
Contacts and Locations
| Tracking Information | |||||
|---|---|---|---|---|---|
| First Submitted Date | May 28, 2019 | ||||
| First Posted Date | July 2, 2019 | ||||
| Last Update Posted Date | September 21, 2020 | ||||
| Estimated Study Start Date | September 18, 2020 | ||||
| Estimated Primary Completion Date | December 7, 2020 (Final data collection date for primary outcome measure) | ||||
| Current Primary Outcome Measures |
relation between HLA subgroups and severity and prevelance of coronary artery lesions [ Time Frame: 20 MAY 2019 - 30 MAY 2019 ] the hla similarity of two sibling patient %80 and the military syntax score %97,7
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| Original Primary Outcome Measures | Same as current | ||||
| Change History | |||||
| Current Secondary Outcome Measures | Not Provided | ||||
| Original Secondary Outcome Measures | Not Provided | ||||
| Current Other Pre-specified Outcome Measures | Not Provided | ||||
| Original Other Pre-specified Outcome Measures | Not Provided | ||||
| Descriptive Information | |||||
| Brief Title | Comparison of the Severity of Coronary Atherosclerosis With Tissue Compliance in Patients Within First Degree Relatives | ||||
| Official Title | Comparison of the Severity and Prevalence of Coronary Atherosclerosis With Tissue Compliance (HLA Similarity ) in Patients Within First Degree Relatives | ||||
| Brief Summary | This study research the similarity of coronary artery lesions according to HLA tissue compatibility in fisrt degree relatives of the patients who just admitted clinic as Acute coronary syndrome and underwent angiyography before . | ||||
| Detailed Description | Coronary artery disease (CAD), which is mainly caused by atherosclerosis, is the most prevalent illness and the leading cause of death worldwide. Increasing evidence suggests that inflammation plays a primordial role in atherogenesis and is closely associated with the major histocompatibility complex (MHC) (human leukocyte antigen [HLA] in humans) molecules. HLA genes are located in 6p21.3, the proteins encoded by these HLA genes have a major role to play in antigen presentation and inflammatory pathways. HLA involvement in inflammation is mainly associated with the HLA-dependent activation of T cells. studies reported that the susceptibility to CAD is related with the polymorphisms in HLA-DRB1. The above evidence indicates that the polymorphisms in HLA class II are associated with the risk of CAD . This study research investigate three objects , firstly what is the similarity of the coronary artery lesions according to the compatability of HLA alleles between the first degree relatives who went angiography before , secondly is there any relation between HLA subtype allels and the coronary artery (RCA ?LAD ? ,CX? and can such a relation be responsible from the lesions in this artery ,finally is there any relation between HLA subtypes and turkish race coronary artery disease | ||||
| Study Type | Observational | ||||
| Study Design | Observational Model: Family-Based Time Perspective: Other |
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| Target Follow-Up Duration | Not Provided | ||||
| Biospecimen | Retention: Samples With DNA Description:
blood sample
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| Sampling Method | Probability Sample | ||||
| Study Population |
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| Condition | Coronary Artery Disease With Myocardial Infarction | ||||
| Intervention | Diagnostic Test: there is not any intervention procedure
there is not any intervention procedure
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| Study Groups/Cohorts | Not Provided | ||||
| Publications * | Xiong Y, Wang L, Mo P, Huang G, Li A, Chai R, Lin X, Zhong Y, Liu B, Ou W, Liu B, Liu SM. Association between HLA-DQB1 alleles and susceptibility to coronary artery disease in Southern Han Chinese. Hum Immunol. 2017 Sep;78(9):540-546. doi: 10.1016/j.humimm.2017.06.003. Epub 2017 Jun 15. | ||||
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* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline. |
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| Recruitment Information | |||||
| Recruitment Status | Recruiting | ||||
| Estimated Enrollment |
60 | ||||
| Original Estimated Enrollment | Same as current | ||||
| Estimated Study Completion Date | January 1, 2021 | ||||
| Estimated Primary Completion Date | December 7, 2020 (Final data collection date for primary outcome measure) | ||||
| Eligibility Criteria |
Inclusion Criteria:
Exclusion Criteria:
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| Sex/Gender |
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| Ages | 18 Years to 70 Years (Adult, Older Adult) | ||||
| Accepts Healthy Volunteers | No | ||||
| Contacts |
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| Listed Location Countries | Turkey | ||||
| Removed Location Countries | |||||
| Administrative Information | |||||
| NCT Number | NCT04004832 | ||||
| Other Study ID Numbers | 2018/543 | ||||
| Has Data Monitoring Committee | No | ||||
| U.S. FDA-regulated Product |
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| IPD Sharing Statement |
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| Responsible Party | Zeki Çetinkaya, TC Erciyes University | ||||
| Study Sponsor | TC Erciyes University | ||||
| Collaborators | Not Provided | ||||
| Investigators |
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| PRS Account | TC Erciyes University | ||||
| Verification Date | September 2020 | ||||
