• Psychometric evaluation of fatigue [ Time Frame: 1 day ]
  The Multidimensional Fatigue Inventory (MFI) is a 20 question self-report instrument designed to measure fatigue. It covers the following dimensions: General Fatigue, Physical Fatigue, Mental Fatigue, Reduced Motivation and Reduced Activity. Each question is graded from 1 ("Yes, that is true") to 5 ("No, that is not true"). Higher scores indicate a higher level of fatigue.
• Quality of life impact of fatigue [ Time Frame: 1 day ]
  The functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) evaluates the impact on quality of life of chronic illness. This is a questionnaire with 13 questions graded according to a Likert scale ranging from 1 to 5 (1 = quite, 5 = not at all).
• Assessment of gait and balance [ Time Frame: 1 day ]
  The Timed Up and Go test (TUG) is a simple test used to assess a person's mobility and requires both static and dynamic balance. It measures the time that a person takes to rise from a chair, walk three meters, turn around, walk back to the chair, and sit down.
• Assesment of lower limb functional strength [ Time Frame: 1 day ]
  The five-repetition sit-to-stand test (5STS) is a test of lower limb function that measures the fastest time taken to stand five times from a chair with arms folded.
• Assesment of walking speed [ Time Frame: 1 day ]
  10 meters gait speed test: measure of the time required to walk 10 meters at the fastest speed possible.
• Electromyographic evaluation: temporal recruitment of the motor units. [ Time Frame: 1 day ]
  The evolution of temporal recruitment through the evaluation of the discharge frequency of the motor units.
• Electromyographic evaluation: Root Mean Square measurement [ Time Frame: 1 day ]
  The average Root Mean Square (RMS) evolution according to the progress of the fatigability protocol, and its link with the developed force.

• Psychometric evaluation of fatigue [ Time Frame: 1 day ]
  The Multidimensional Fatigue Inventory (MFI) is a 20-item self-report instrument designed to measure fatigue. It covers the following dimensions: General Fatigue, Physical Fatigue, Mental Fatigue, Reduced Motivation and Reduced Activity.
• Quality of life impact of fatigue [ Time Frame: 1 day ]
  The functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) evaluates the impact on quality of life of chronic illness. This is a questionnaire with 13 questions graded according to a Likert scale ranging from 1 to 5 (1 = quite, 5 = not at all).
• Assessment of gait and balance [ Time Frame: 1 day ]
  The Timed Up and Go test (TUG) is a simple test used to assess a person's mobility and requires both static and dynamic balance. It measures the time that a person takes to rise from a chair, walk three meters, turn around, walk back to the chair, and sit down.
• Assesment of lower limb functional strength [ Time Frame: 1 day ]
  The five-repetition sit-to-stand test (5STS) is a test of lower limb function that measures the fastest time taken to stand five times from a chair with arms folded.
• Assesment of walking speed [ Time Frame: 1 day ]
  10 meters gait speed test: measure of the time required to walk 10 meters at the fastest speed possible.
• Electromyographic evaluation: temporal recruitment of the motor units. [ Time Frame: 1 day ]
  The evolution of temporal recruitment through the evaluation of the discharge frequency of the motor units.
• Electromyographic evaluation: Root Mean Square measurement [ Time Frame: 1 day ]
  The average Root Mean Square (RMS) evolution according to the progress of the fatigability protocol, and its link with the developed force.

The evolution of chronic kidney disease (CKD) causes a systemic upheaval on the body and a deep fatigue is very often described by patients (50-70% of the patients) even before the start of dialysis (pre-dialysis). This fatigue has many origins, and one of them probably stems from a deterioration of neuromuscular abilities. Very few studies have examined the physiological aspects of neuromuscular fatigue in pre-dialysis patients, and shedding light on potential deficits at this level would allow safe and efficient implementation of adapted physical activity programs.

Our study aims to characterize the pathophysiology of neuromuscular capabilities in chronic advanced renal failure in pre-dialysis patients.

Chronic Kidney Disease (CKD) group:

Patients with chronic kidney disease and a glomerular filtration rate less than 60 ml/min of creatinine.

Control group:

The control group will consist of a group of people from the same age group as the CKD group but without chronic kidney disease. The exclusion criteria apply to this group. They will be selected from the spouses and other volunteers.

• Chronic Kidney Failure
• Chronic Kidney Disease stage3
• Chronic Kidney Disease, Stage 4 (Severe)
• Chronic Kidney Disease Stage 5
• Fatigue

• Chronic Kidney Disease (CKD) Patients
  Patients with chronic kidney disease and a glomerular filtration rate less than 60 ml/min of creatinine. Patients will perform a hand grip fatigability test with their dominant hand, followed by a Timed Up and Go Test (TUG-Test), a Five-repetition sit-to-stand-test (5STS-Test) and a10 meters gait speed test.
  Intervention: Diagnostic Test: Discrimination of neuromuscular alterations protocol
• Control cohort
  The control cohort will consist of a group of people from the same age group as the CKD group but without chronic kidney disease. The exclusion criteria apply to this group. They will be selected from the spouses and other volunteers. This group will also perform a hand grip fatigability test with their dominant hand, followed by a Timed Up and Go Test (TUG-Test), a Five-repetition sit-to-stand-test (5STS-Test) and a10 meters gait speed test.
  Intervention: Diagnostic Test: Discrimination of neuromuscular alterations protocol

Inclusion Criteria:

• Adult patients (Age> 18 years) who have signed the informed consent form
• Social security coverage
• For patients in the Chronic Kidney Disease group: Glomerular filtration rate less than 60 ml/min of creatinine for more than three months

Exclusion Criteria:

• Dermatological conditions of the upper limbs which would contra-indicate Electromyographic electrodes being positioned
• Gestating women
• Patients with known neuromuscular conditions
• Patients with dementia
• Patients with acute heart failure
• Patients with a history of surgery of the evaluated limb
• Patients included in an interventional study involving administration of treatments other than routine care
• For the patients in the Chronic Kidney Disease group: patients currently undergoing dialysis or in a pre-dialysis program (e.g. with a dialysis fistula already in place).