Many patients with Parkinson's disease (Pd) don't respect medication prescriptions. Non-adherence is caused by several factors among which three play an important role: treatment complexity, cognitive decline, and patient-provider communication. One way for improving medication adherence in these patients is to identify the best way for adapting medication prescription presentation to these patients. This study is focused on prescriptions displayed on touch-screens and tablets.

This exploratory study aims at identifying the best format for presenting medication prescription to Pd patients. An experiment with Pd patients and healthy volunteers is carried out to analyze their behavior while filling a virtual pillbox from a education prescription presented electronically in different formats on a tablet or a touchscreen. A table format and a verbal format are compared to determine the most effective design for presenting medication schedules. A facilitating effect of the table format is hypothesized.

Many Pd patients are non-adherent to their treatments. Because Pd patients are generally over 60 years old, suffer from cognitive disorders, and have complex medication regimens, taking medications as prescribed is a too complex cognitive task for them. It supposes the ability to understand the prescription, to plan and memorize the actions to carry out and to remember them while executing them. As prescriptions are communicated to patients via procedural documents, it should be possible to improve patient's comprehension by using a format suitable for their needs and characteristics. Previous studies with elderly people suggest that the table format is more effective than the textual format. However no study addressed this question with Pd patients.

One-hundred and twenty patients with Parkinson's disease and 120 healthy volunteers participate voluntarily to the study. Their task consists in reading on a touch screen, or on a tablet, two fictive medication prescriptions. One is presented in a table format and the other in a textual format. Each prescription comprises two regular medications (same doses and moments of the day) and two irregular medications (different doses or different moments). For each prescription, participants must fill a virtual pillbox displayed on the screen as prescribed in the prescription. Prescriptions and pillboxes are displayed by a tablet software specifically designed to record in real time all participant's actions and related chronometric data. Half participants perform the task in the " tablet condition ", and the other half in the " touch-screen " condition. In the touch-screen condition an eye-tracker is used to record eye fixations and scanpaths in real time. Once the 2nd pillbox filling is finished a battery of cognitive tests and questionnaires is administered to participants to identify Pd subtypes of impaired performances.

The main hypothesis predicts an effect of the format of prescriptions. More precisely, it consists in two concurrent hypotheses. H1a (the mental model model hypothesis): the table format should facilitate the pillboxes filling in the parkinsonian group and in the healthy volunteer group by facilitating the elaboration of an accurate mental model. H1b (the working memory load hypothesis): because parkinsonian patients are frequently impaired in visuospatial tasks, the tabular format could have no effect or could have a negative effect only in this group. A correlation between cognitive subtypes identified by cluster analyses and task performances is expected. Several secondary hypotheses will be tested.

• Other: reading a table format prescription on a touch screen
  Task consists in reading on a touch screen, or on a tablet, two fictive medication prescriptions. One is presented in a table format and the other in a textual format. Each prescription comprises two regular medications (same doses and moments of the day) and two irregular medications (different doses or different moments).
• Other: reading a textual format prescription on a touch screen
  Task consists in reading on a touch screen, or on a tablet, two fictive medication prescriptions. One is presented in a table format and the other in a textual format. Each prescription comprises two regular medications (same doses and moments of the day) and two irregular medications (different doses or different moments).
• Other: filling a virtual pillbox displayed on the screen as prescribed in the prescription
  filling a virtual pillbox displayed on the screen as prescribed in the prescription
• Other: eye-tracker
  In the touch-screen condition an eye-tracker is used to record eye fixations and scanpaths in real time.
• Other: cognitive tests and questionary
  Once the 2nd pillbox filling is finished a battery of cognitive tests and questionnaires is administered to participants to identify Pd subtypes of impaired performances.

• Active Comparator: textual prescription healthy volunteers
  Interventions:

  • Other: reading a textual format prescription on a touch screen
  • Other: filling a virtual pillbox displayed on the screen as prescribed in the prescription
  • Other: eye-tracker
  • Other: cognitive tests and questionary
• Active Comparator: table prescription healthy volunteers
  Interventions:

  • Other: reading a table format prescription on a touch screen
  • Other: filling a virtual pillbox displayed on the screen as prescribed in the prescription
  • Other: eye-tracker
  • Other: cognitive tests and questionary
• Experimental: textual prescription Parkinson's disease patients
  Interventions:

  • Other: reading a textual format prescription on a touch screen
  • Other: filling a virtual pillbox displayed on the screen as prescribed in the prescription
  • Other: eye-tracker
  • Other: cognitive tests and questionary
• Experimental: table prescription Parkinson's disease patient
  Interventions:

  • Other: reading a table format prescription on a touch screen
  • Other: filling a virtual pillbox displayed on the screen as prescribed in the prescription
  • Other: eye-tracker
  • Other: cognitive tests and questionary

Inclusion Criteria:

• all participants must have French as mother tongue,
• be able to sign the written informed consent form and must have reached the age of majority.
• Patients with Pd must have been diagnosed by a neurologist of the Amiens CHU (University Hospital Centre) more than 3 years ago, and must be in a ON period when participating to the two sessions.

Exclusion Criteria:

• photosensitive epilepsy,
• dyschromatopsias,
• not corrected visual acuity,
• dementia indicated by a Mini Mental State Examination score < 24,
• alcoholism or other drug addictions conditions known to impair mental status
• acute psychiatric or neurologic illness,
• failing to the training phase.
• Patients with Pd must not have other parkinsonian syndrome nor neurological, psychiatric or motor disorders, other than due to Pd.