• Response rate [ Time Frame: The assessment period for this outcome will be from the start of recruitment until the inclusion of the last patient, which will be about 1 year. ]
  The investigators will assess the amount of eligible patients which are willing to participate in the study relative to the amount of patients who were invited to participate.
• Patient adherence [ Time Frame: During the intervention phase for each patient, which will be about sixth months. ]
  Patient adherence will be assessed via documentation of patient drop-outs. In detail, we will document whether patients leave the study during the treatment (and if yes, at what stage).
• Patient satisfaction [ Time Frame: Assessed only once for each patient, immediately after the patient has completed the intervention. ]
  Assessed by a questionnaire (Working Alliance Inventory - short form revised). The total sum score across the 12 items, rated on a five-point Likert scale, will be presented (ranging from 12 to 60). Higher values present higher satisfaction.

• Level of quality of life [ Time Frame: Assessed at three time points: before the intervention, immediately after the intervention and 3 months after the intervention ]
  Assessed by a questionnaire, the Amyotrophic Lateral Sclerosis Assessment Questionnaires - short form (ALSAQ-5). The total score across the 5 items, rated on a 4-point Likert scale, will be presented (range: 0 - 20). Higher values indicate higher quality of life.
• Level of depressive symptomatology [ Time Frame: Assessed at three time points: before the intervention, immediately after the intervention and 3 months after the intervention ]
  Assessed by a questionnaire, the ALS-Depression-Inventory (ADI-12). The sum score across all 12 items, each rated on a 4-point Likert-scale, will be reported (range: 12-48). Higher values indicate higher levels of depression.
• Level of functioning [ Time Frame: Assessed at three time points: before the intervention, immediately after the intervention and 3 months after the intervention ]
  Assessed by a questionnaire, the revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R). The total sum score across the 15 items, each rated on a 5-point LIkert scale, will be reported (range: 0-60). Higher values indicate a higher level of functioning.

Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that is inevitably fatal. To be diagnosed with a terminal illness such as ALS deeply affects one's personal existence and goes along with significant changes regarding the physical, emotional, and social domains of the patients' life. ALS patients have to face a rapidly debilitating physical decline which restrains mobility and impairs all activities of daily living. In addition, they are confronted with their own mortality. This progressive loss of autonomy and fears about the future may lead to a sense of hopelessness and loss of quality of life, which in turn may even result in thoughts about physician-assisted suicide.

Concrete aims: Given the high emotional strain in this patient group, this study aims to apply a manualized psychotherapeutic intervention to relieve distress and promote psychological well-being on ALS patients. This short-term intervention (up to six sessions) was originally developed for advanced cancer patients. "Managing Cancer and Living Meaningfully (CALM)" focuses on the four dimensions: (i) symptom management and communication with healthcare providers, (ii) changes in self and relations with close others, (iii) spirituality, sense of meaning and purpose and (iv) thinking of the future, hope, and mortality.

Methodology: For these aims mentioned above, the investigators will conduct a feasibility study, i.e., a pilot study before a future randomized controlled trial can be planned in detail. The design of this pilot intervention will be a non-randomised prospective non-controlled before-and-after study, in which observations will be made only in a patient group (n = 5) that receives the intervention (IG). No control group will be recruited. Assessments will be conducted on the three measurement points: before the therapy (T0), after the intervention (T1) and 3 months after the intervention (T2).This study is intended to test out the standard operating procedures, evaluate the feasibility, acceptance and adherence to the study protocol as well as preliminary efficacy of the intervention.

Recruitment: Patients will be consecutively recruited in the Clinic of Neurology at the University Medical Center of Leipzig.

Duration: The duration for patients will be about 9 months (6 months intervention, 3 month-follow-up assessment). The duration of the whole study will be 12 months.

• Amyotrophic Lateral Sclerosis
• Psychological Stress

Inclusion Criteria:

• confirmed diagnosis of Amyotrophic Lateral Sclerosis
• minimum age of 18 years
• fluent in German language
• ability to visit the institution providing the intervention at the start of therapy (in the course of treatment, telephone-sessions may be offered)
• ability to report on thoughts and feelings (by speaking, writing or via communication devices)
• cognitive ability to give written informed consent
• expected remaining lifetime of at least 9 months

Exclusion Criteria:

• inability for communicate (neither via speaking, writing or communication devices)
• currently in psychotherapeutic treatment