• HIV/AIDS
• Alcoholic Hepatitis

• Other: Alcoholic Hepatitis Group
  Alcoholic hepatitis is defined as having a total bilirubin level >3mg/dL and AST level>50U/L
• Other: Heavy Drinking Controls without Hepatitis
  Normal levels of AST, ALT and total bilirubin and without evidence of cirrhosis or hepatosplenomegaly

• With alcoholic hepatitis
  HIV-positive patients receiving antiretroviral therapy and who are heavy drinkers with high bilirubin and AST levels.
  Intervention: Other: Alcoholic Hepatitis Group
• Without alcoholic hepatitis
  HIV-positive patients receiving antiretroviral therapy and who are heavy drinkers without high bilirubin and AST levels.
  Intervention: Other: Heavy Drinking Controls without Hepatitis

Inclusion Criteria:

• Both Groups: Age equal to or greater than 18 years
• HIV infection documented by any licensed rapid HIV test or HIV enzyme or chemiluminescence immunoassay (E/CIA) test kit at any time prior to study entry and confirmed by a licensed Western blot, a second antibody test by a method other than the initial rapid HIV and/or E/CIA, or by at least one detectable HIV-1 RNA level
• Receipt of stable antiretroviral therapy of any kind for at least 90 days prior to the baseline study visit
• The most recent HIV-1 RNA level must be <200 copies/mL obtained as part of routine clinical care within 90 days prior to the main study visit
• NOTE: There is no CD4 cell count eligibility criterion for this study.
• Current alcoholism defined as >40g/day and >60g/day of alcoholic intake on average for a minimum of six months and within 90 days of the baseline visit in women and men, respectively

• For Group 1 (Alcoholic Hepatitis Group), the presence of alcoholic hepatitis is defined by

  • Per most recently obtained routine clinical care laboratories, a total bilirubin > 3mg/dL and AST >50U/L, both within 90 days of the baseline study visit
  • For Group 1, participants who have become alcohol abstinent within 14 days of the baseline visit will still be allowed to participate

• For Group 2 (Heavy drinking controls without hepatitis):

  • The most recent AST, ALT, and total bilirubin levels must be within normal limits. However, if the bilirubin level is increased due to suspected Gilbert's syndrome or due to current use of atazanavir, then the participant will be eligible.
  • There must not be evidence of current hepatosplenomegaly by examination or imaging obtained previously
  • There must not be stigmata of cirrhosis (spider angiomata, jaundice, encephalopathy, palmar erythema, ascites, intestinal varices).

Exclusion Criteria:

• Inability to complete written, informed consent
• Incarceration at the time of screening or main study visit
• Abstinence from alcohol >2 weeks prior to the baseline study visit
• Liver disease considered to be due to any etiology besides alcohol use
• Diagnosed disease or process associated with increased systemic inflammation (including, but not limited to, systemic lupus erythematosus, inflammatory bowel diseases, other collagen vascular/autoimmune diseases)
• Known active hepatitis B (defined as hepatitis B surface antigen positive with quantifiable HBV DNA viral load) or active hepatitis C (defined as quantifiable hepatitis C RNA viral load)
• Fever, defined as T ≥ 38.0C within 48 hours prior to any study visit
• Therapy for acute infection or other serious medical illnesses within 7 days of study visit
• Malignancy requiring active treatment or had completed treatment within 90 days of any study visit (excluding skin-limited Kaposi sarcoma)
• Pregnancy or breastfeeding within 14 days of any study visit
• Receipt of investigational agents, cytotoxic chemotherapy, systemic or topical glucocorticoids (of any dose), or anabolic steroids (including physiologic testosterone replacement therapy) within 14 days of study visit
• Active illicit drug use (besides marijuana) via any intake route (inhalation, smoking, injection)