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出境医 / 临床实验 / Mirror Neurons in Older Participants (MNOP)
Mirror Neurons in Older Participants (MNOP)
Study Description
Brief Summary:
A critical problem facing aging adults is muscle weakness. Whereas scientists have traditionally attributed the loss of muscle strength with aging to muscle atrophy, emerging evidence suggests that impairments in the neuromuscular system's ability to voluntarily generate force plays a more central role than previously appreciated. One area that has not yet been investigated includes the role that observing another's actions - thereby activating mirror neurons - plays in muscle force generation. Therefore, the purpose of this study is to examine the acute effects of action observation on muscular strength, voluntary muscle activation, and cortical excitability and inhibition in older adults.
| Condition or disease | Intervention/treatment | Phase |
|---|---|---|
| Muscle Weakness Dynapenia Sarcopenia | Other: Action Observation | Not Applicable |
Detailed Description:
A critical problem facing aging adults is muscle weakness. Whereas scientists have traditionally attributed the loss of muscle strength with aging to atrophic effects, emerging evidence suggests that impairments in the neuromuscular system's ability to voluntarily generate force plays a more central role than previously appreciated. One area that has not yet been investigated includes the role that observing another's actions - thereby activating mirror neurons - plays in muscle force generation. Therefore, the purpose of this study is to examine the acute effects of action observation on muscular strength, voluntary activation, and cortical excitability and inhibition in older adults. Following a thorough familiarization visit, twenty-five men and women ≥60 years of age will complete three action observation sessions in a randomized, counterbalanced manner: 1) observation of very strong hand/wrist contractions, 2) observation of very weak hand/wrist contractions, and 3) a control condition. Maximal voluntary contractions (MVCs) of the wrist flexors will be performed before and after observation sessions. Percent voluntary activation will be determined via the interpolated twitch technique. Single-pulse transcranial magnetic stimulation (TMS) and electromyographic (EMG) recordings from the flexor carpi radialis and first dorsal interosseous will be used to quantify cortical excitability and inhibition, via motor evoked potential amplitude and silent period duration, respectively. The hypothesis of this study is that observation of strong muscle contractions will acutely increase muscle strength, and such changes will be facilitated by enhanced corticospinal excitability and decreased inhibition. In contrast, it is hypothesized that observation of very weak contractions will cause no such efforts or even acute muscle weakness. Collectively, we propose that manipulation of mirror neurons is a worthwhile strategy for clinicians hoping to induce neuromuscular adaptations in older adults, particularly in settings where movement of a joint is painful or infeasible (e.g., bedrest or immobilization).
Study Design
| Study Type : | Interventional (Clinical Trial) |
| Estimated Enrollment : | 25 participants |
| Allocation: | Randomized |
| Intervention Model: | Crossover Assignment |
| Masking: | None (Open Label) |
| Primary Purpose: | Basic Science |
| Official Title: | Mirror Neurons in Older Participants (Project MNOP): Acute Effects of Action Observation on Muscle Strength/Weakness and Neurophysiological Factors in Older Adults |
| Actual Study Start Date : | December 20, 2018 |
| Estimated Primary Completion Date : | December 1, 2021 |
| Estimated Study Completion Date : | April 1, 2022 |
Arms and Interventions
| Arm | Intervention/treatment |
|---|---|
| Muscle strength condition |
Other: Action Observation
Strength, voluntary activation, and cortical responses to three conditions will be measured: 1) action observation of very strong, forceful contractions of the hand and wrist flexors 2) action observation of very weak, feeble contractions of the hand and wrist flexors 3) no action observation. Experimental conditions will be randomized and counterbalanced.
|
| Muscle weakness condition |
Other: Action Observation
Strength, voluntary activation, and cortical responses to three conditions will be measured: 1) action observation of very strong, forceful contractions of the hand and wrist flexors 2) action observation of very weak, feeble contractions of the hand and wrist flexors 3) no action observation. Experimental conditions will be randomized and counterbalanced.
|
| No Intervention: Control |
Outcome Measures
Primary Outcome Measures :
- Muscle Strength [ Time Frame: 5 minutes ]Isometric muscle strength of the non-dominant hand and wrist flexors will be assessed during maximal voluntary contractions (MVCs).
Secondary Outcome Measures :
- Voluntary Activation [ Time Frame: 5 minutes ]Percent voluntary activation will be quantified during the MVCs to determine each participant's ability to maximally activate their wrist flexor muscles voluntarily.
- Corticospinal excitability [ Time Frame: 5 minutes ]Transcranial magnetic stimulation will be used to quantify corticospinal excitability throughout the study.
Eligibility Criteria
| Ages Eligible for Study: | 60 Years and older (Adult, Older Adult) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | Yes |
Criteria
Inclusion Criteria:
- Healthy men and women ≥60 years of age
Exclusion Criteria:
- Neuromuscular disease (e.g. Parkinson's, MS, ALS)
- Metabolic disease (e.g. diabetes, thyroid disorder, metabolic syndrome)
- Arthritis in the upper limbs (hands, arms, shoulders)
- Trouble using or controlling one's muscles
- History of cancer
- History of stroke
- History of heart attack
- Use of an assistive walking device or other mobility aids
- Physician mandated contraindication to exercise within the last 6 months
- Epilepsy or history of convulsions/seizures
- History of fainting or syncope
- History of head trauma that was diagnosed as concussion or was associated with loss of consciousness
- History of hearing problems or tinnitus
- Cochlear implants
- Implanted metal in the brain, skull, or elsewhere in the body
- Implanted neurotransmitter
- Cardiac pacemaker or intracardiac lines
- Medication infusion device
- Past problems with brain stimulation
- Past problems with MRI
- Use of muscle relaxants or benzodiazepines
- Allergy to rubbing alcohol
- Any other health related illnesses that would prohibit a participant from physical performance testing
- Lack of transportation to and from the laboratory
Contacts and Locations
Contacts
| Contact: Kylie K. Harmon, M.S. | (407)823-0600 | kharmon@knights.ucf.edu | |
| Contact: Ryan M. Girts | (407)823-0600 | ryangirts@knights.ucf.edu |
Locations
| United States, Florida | |
| UCF Neuromuscular Plasticity Laboratory | Recruiting |
| Orlando, Florida, United States, 32826 | |
| Contact: Matt S. Stock, Ph.D. 407-823-0600 matt.stock@ucf.edu | |
Sponsors and Collaborators
University of Central Florida
Investigators
| Principal Investigator: | Matt S. Stock, Ph.D. | University of Central Florida |
| Tracking Information | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| First Submitted Date ICMJE | May 8, 2019 | ||||||||
| First Posted Date ICMJE | May 13, 2019 | ||||||||
| Last Update Posted Date | April 29, 2021 | ||||||||
| Actual Study Start Date ICMJE | December 20, 2018 | ||||||||
| Estimated Primary Completion Date | December 1, 2021 (Final data collection date for primary outcome measure) | ||||||||
| Current Primary Outcome Measures ICMJE |
Muscle Strength [ Time Frame: 5 minutes ] Isometric muscle strength of the non-dominant hand and wrist flexors will be assessed during maximal voluntary contractions (MVCs).
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| Original Primary Outcome Measures ICMJE | Same as current | ||||||||
| Change History | |||||||||
| Current Secondary Outcome Measures ICMJE |
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| Original Secondary Outcome Measures ICMJE | Same as current | ||||||||
| Current Other Pre-specified Outcome Measures | Not Provided | ||||||||
| Original Other Pre-specified Outcome Measures | Not Provided | ||||||||
| Descriptive Information | |||||||||
| Brief Title ICMJE | Mirror Neurons in Older Participants | ||||||||
| Official Title ICMJE | Mirror Neurons in Older Participants (Project MNOP): Acute Effects of Action Observation on Muscle Strength/Weakness and Neurophysiological Factors in Older Adults | ||||||||
| Brief Summary | A critical problem facing aging adults is muscle weakness. Whereas scientists have traditionally attributed the loss of muscle strength with aging to muscle atrophy, emerging evidence suggests that impairments in the neuromuscular system's ability to voluntarily generate force plays a more central role than previously appreciated. One area that has not yet been investigated includes the role that observing another's actions - thereby activating mirror neurons - plays in muscle force generation. Therefore, the purpose of this study is to examine the acute effects of action observation on muscular strength, voluntary muscle activation, and cortical excitability and inhibition in older adults. | ||||||||
| Detailed Description | A critical problem facing aging adults is muscle weakness. Whereas scientists have traditionally attributed the loss of muscle strength with aging to atrophic effects, emerging evidence suggests that impairments in the neuromuscular system's ability to voluntarily generate force plays a more central role than previously appreciated. One area that has not yet been investigated includes the role that observing another's actions - thereby activating mirror neurons - plays in muscle force generation. Therefore, the purpose of this study is to examine the acute effects of action observation on muscular strength, voluntary activation, and cortical excitability and inhibition in older adults. Following a thorough familiarization visit, twenty-five men and women ≥60 years of age will complete three action observation sessions in a randomized, counterbalanced manner: 1) observation of very strong hand/wrist contractions, 2) observation of very weak hand/wrist contractions, and 3) a control condition. Maximal voluntary contractions (MVCs) of the wrist flexors will be performed before and after observation sessions. Percent voluntary activation will be determined via the interpolated twitch technique. Single-pulse transcranial magnetic stimulation (TMS) and electromyographic (EMG) recordings from the flexor carpi radialis and first dorsal interosseous will be used to quantify cortical excitability and inhibition, via motor evoked potential amplitude and silent period duration, respectively. The hypothesis of this study is that observation of strong muscle contractions will acutely increase muscle strength, and such changes will be facilitated by enhanced corticospinal excitability and decreased inhibition. In contrast, it is hypothesized that observation of very weak contractions will cause no such efforts or even acute muscle weakness. Collectively, we propose that manipulation of mirror neurons is a worthwhile strategy for clinicians hoping to induce neuromuscular adaptations in older adults, particularly in settings where movement of a joint is painful or infeasible (e.g., bedrest or immobilization). | ||||||||
| Study Type ICMJE | Interventional | ||||||||
| Study Phase ICMJE | Not Applicable | ||||||||
| Study Design ICMJE | Allocation: Randomized Intervention Model: Crossover Assignment Masking: None (Open Label) Primary Purpose: Basic Science |
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| Condition ICMJE |
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| Intervention ICMJE | Other: Action Observation
Strength, voluntary activation, and cortical responses to three conditions will be measured: 1) action observation of very strong, forceful contractions of the hand and wrist flexors 2) action observation of very weak, feeble contractions of the hand and wrist flexors 3) no action observation. Experimental conditions will be randomized and counterbalanced.
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| Study Arms ICMJE |
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| Publications * | Not Provided | ||||||||
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* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline. |
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| Recruitment Information | |||||||||
| Recruitment Status ICMJE | Recruiting | ||||||||
| Estimated Enrollment ICMJE |
25 | ||||||||
| Original Estimated Enrollment ICMJE | Same as current | ||||||||
| Estimated Study Completion Date ICMJE | April 1, 2022 | ||||||||
| Estimated Primary Completion Date | December 1, 2021 (Final data collection date for primary outcome measure) | ||||||||
| Eligibility Criteria ICMJE |
Inclusion Criteria:
Exclusion Criteria:
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| Sex/Gender ICMJE |
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| Ages ICMJE | 60 Years and older (Adult, Older Adult) | ||||||||
| Accepts Healthy Volunteers ICMJE | Yes | ||||||||
| Contacts ICMJE |
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| Listed Location Countries ICMJE | United States | ||||||||
| Removed Location Countries | |||||||||
| Administrative Information | |||||||||
| NCT Number ICMJE | NCT03946709 | ||||||||
| Other Study ID Numbers ICMJE | SBE-18-14657 | ||||||||
| Has Data Monitoring Committee | No | ||||||||
| U.S. FDA-regulated Product |
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| IPD Sharing Statement ICMJE |
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| Responsible Party | Matt Stock, University of Central Florida | ||||||||
| Study Sponsor ICMJE | University of Central Florida | ||||||||
| Collaborators ICMJE | Not Provided | ||||||||
| Investigators ICMJE |
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| PRS Account | University of Central Florida | ||||||||
| Verification Date | April 2021 | ||||||||
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ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP |
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