• cognitive function [ Time Frame: 3 years ]
  Hopkins Verbal Learning Test-Revised (HVLT-R);
• cognitive function [ Time Frame: 3 years ]
  Controlled Oral Word Association Test (COWA);
• cognitive function [ Time Frame: 3 years ]
  Trail Making Test (TMT)
• Physical fitness [ Time Frame: 3 years ]
  six-minute walk test (6MWT)
• endocrine function [ Time Frame: 3 years ]
  measurement of gonadal and pituitary function in blood
• Quality of life of caregivers [ Time Frame: 3 years ]
  Caregiver Quality of Life Index-Cancer (CQOLC)
• muscle strength [ Time Frame: 3 years ]
  Maximal voluntary isometric muscle force of the right and left extremity of extension of the knee, flexion of the knee, flexion of the elbow, extension of the elbow and grip-strength of the hand will be measured using a hand-held dynamometer.

Rationale: Tremendous anti-tumor effects have been achieved using immune checkpoint inhibitors for melanoma and NSCLC with long lasting responses of more than 2 years in a substantial subgroup of patients. However, we are still largely unaware of the health-related quality of life of these patients. We should carefully and thoroughly assess the long-term burden of disease and treatment toxicity.

Objective: Primary Objective: to investigate health-related quality of life (HRQoL) of patients surviving 2 years or more after the first cycle of an immune checkpoint inhibitor for melanoma or NSCLC. Secondary Objectives: to assess neurocognitive function, endocrine function, cardiovascular risk, physical fitness, mood disorders, sexual problems, work participation in patients surviving 2 years or more after the first cycle of immune checkpoint inhibitor; to assess quality of life of the caregivers of these patients.

Study design: Observational cross-sectional study. Study population: Patients (age ≥18 years) with melanoma or NSCLC ≥2 years since treatment with at least one cycle of immune checkpoint inhibitor (CTLA-4 inhibitor, PD-(L)1 inhibitor, or both).

Main study parameters/endpoints: health-related quality of life (HRQoL) as measured using the EORTC Quality of life questionnaire (QLQ-C30). Secondary study parameters: possible late effects (neurocognitive dysfunction, endocrine disorders, dermatologic complaints, sexual disorders and infertility, increased cardiovascular risk, and fatigue), physical fitness, psychosocial issues related to work/education, mood disorders (anxiety and depression), patient and treatment-related factors potentially influencing development of late effects, well-being, and quality of life of caregivers.

• Melanoma
• Non Small Cell Lung Cancer

Inclusion Criteria:

1. Patient with melanoma or NSCLC ≥2 years since treatment with at least one cycle of immune checkpoint inhibitor (CTLA-4 inhibitor, PD-(L)1 inhibitor, or both) within the Department of Medical Oncology or Pulmonary Oncology of the UMCG.
2. Age ≥18 years at time of immune checkpoint inhibitor treatment
3. All previous or subsequent therapies allowed, including (brain) irradiation, surgery for metastases, chemotherapy, and targeted therapy, provided stable clinical situation at time of inclusion

Exclusion Criteria:

1. Switch of systemic therapy or local antitumor intervention (surgery, radiotherapy) during last 2 months
2. Inability to understand or abide to the study protocol
3. Debilitating psychiatric illness
4. Previous treatment for malignancy other than melanoma (excluding non-melanoma skin cancer, cervical intra-epithelial neoplasia (CIN) or carcinoma in situ of breast)