• Peak Plasma Concentration (Cmax) [ Time Frame: 1 day,7 days after taking drugs ]
  To evaluate the Peak Plasma Concentration (Cmax) after taking drugs
• Area under the plasma concentration versus time curve (AUC) [ Time Frame: 1 day,7 days after taking drugs ]
  To evaluate the AUC after taking drugsl
• Time to maximum plasma concentration （Tmax） [ Time Frame: 1 day,7 days after taking drugs ]
  To evaluate the Tmax after taking drugs
• terminal half-life （T1/2） [ Time Frame: 1 day,7 days after taking drugs ]
  To evaluate the T1/2 after taking drugs
• inhibition of platelet aggregation [ Time Frame: 1 day,7 days after taking drugs ]
  To evluate the inhibition of platelet aggregation assessed by Verifynow System after taking drugs

• Healthy Subjects
• PK/PD

• Drug: Vicagrel 6mg
  Vicagrel 24mg loading followed by 6mg/day for 6 days
• Drug: Clopidogrel 75mg
  Clopidogrel 300mg loading followed by 75mg/day for 6 days

• Experimental: Vicagrel
  Vicagrel 24mg loading followed by 6mg/day for 6 days
  Intervention: Drug: Vicagrel 6mg
• Active Comparator: Clopidogrel
  Clopidogrel 300mg loading followed by 75mg/day for 6 days
  Intervention: Drug: Clopidogrel 75mg

Inclusion Criteria:

• Voluntary signing of informed consent before the trial, and full understanding of the experimental content, process and possible adverse reactions;
• Subjects with ability and adherence to trial protocol;
• Subjects (including partners) voluntarily take effective contraceptive measures from screening to the last study drug administration within 6 months;
• Male and female aged 18-45,gender is unlimited (including 18 and 45 years old);
• Male Weight ≥50 kg, female Weight ≥ 45 kg, and BMI ranging from 18 to 28 kg/m2 (including critical values);
• Physical examination, normal or abnormal vital signs have no clinical significance (reference range of vital signs: systolic blood pressure 90-150 mmHg, diastolic blood pressure 50-95 mmHg, pulse 50-110 beats/min, body temperature 35.5-37.2 °C);
• CYP2C19 rapid metabolizers (CYP2C19*1/*1), or intermediate metabolizers (CYP2C19*1/*2, CYP2C19*1/*3), or poor metabolizers (CYP2C19*2/*2, CYP2C19*2/* 3, CYP2C19*3/*3).

Exclusion Criteria:

• More than 5 cigarettes per day 3 months before the trial;
• History of allergies or allergies to the drug (two or more drugs or food allergies);
• History of drug and/or alcohol abuse (14 units of alcohol per week: 1 unit = 285 mL of beer, or 25 mL of spirits, or 100 mL of wine);
• Donate blood or massive blood loss (> 450 mL) within 3 months prior to formal screening;
• Take any drug that alters the activity of CYP450s within 28 days before the formal screening;
• Take any prescription, non-prescription, any vitamin or herbal medicine within 14 days of the formal screening;
• Take special diet (including dragon fruit, mango, grapefruit, etc.) within 2 weeks before the formal screening, or have strenuous exercise, or other factors affecting drug absorption, distribution, metabolism, excretion, etc.;
• Taking inhibitors or inducers of the CYP3A4, P-gp or Bcrp Currently, such as itraconazole, ketoconazole or dronedarone;
• Recently there have been major changes in diet or exercise habits;
• Taking other research drugs or participating in clinical trials within 3 months before taking the study drug;
• History of dysphagia or any gastrointestinal disease affecting drug absorption;
• Have any disease that increases the risk of bleeding, such as acute gastritis, stomach and duodenal ulcers, thrombocytopenic purpura, hemophilia, and so on;
• ECG abnormalities have clinical significance;
• Female subjects are in lactation or have a positive of pregnancy test;
• Clinical laboratory abnormalities have clinical significance or other clinically significant abnormalities (including but not limited to gastrointestinal, kidney, liver, nerve, blood, endocrine, tumor, lung, immune, mental or cardiovascular and cerebrovascular diseases);
• Infectious diseases (two pairs of hepatitis B, hepatitis C antibodies, HIV, Treponema pallidum antibodies) have positive results;
• Acute disease or concomitant medication from the screening to the study;
• Taking chocolate, any food or drink with caffeine or jaundice-rich within 48 hours before taking the study drug;
• Any alcoholic product or alcohol breath test positive within 24 hours before taking the study drug;
• Urine drug test (morphine, marijuana) is positive;
• The investigator believes that there are other factors who are not suitable for participating in the test.