• Height evolution of infants [ Time Frame: from 0 to 6 months ]
  data in centimeters
• BMI evolution of infants [ Time Frame: from 0 to 6 months ]
  data in kg/m²
• Head circumference evolution of infants [ Time Frame: from 0 to 6 months ]
  data in centimeters
• Number of colic per day [ Time Frame: from 0 to 6 months ]
  Evaluation during 3 consecutives days every month.
• Consistency of stool [ Time Frame: from 0 to 6 months ]
  Evaluation during 3 consecutive days every month via Bristol scale. According to the bristol scale, seven types of stool are considered: Type 1: Separate hard lumps, like nuts (hard to pass) Type 2: Sausage-shaped, but lumpy Type 3: Like a sausage but with cracks on its surface Type 4: Like a sausage or snake, smooth and soft Type 5: Soft blobs with clear cut edges (easy to pass) Type 6: Fluffy pieces with ragged edges, a mushy stool Type 7: Watery, no solid pieces, entirely liquid The mean of stool type during 3 days is considered.
• Number of regurgitation [ Time Frame: from 0 to 6 months ]
  Evaluation during 3 consecutive days every month via Vandenplas scale. According to the Vandenplas scale, seven score are considered: 0 0-2 episodes/day

  1. ≥3-≤5 of small volume
  2. >5 episodes of >1 coffee spoon
  3. >5 episodes of half of the feedings in < half of the feedings
  4. Continuous regurgitations of small volumes >30 min after each feeding
  5. Regurgitation of half to complete volume of a feeding in at least half of the feedings
  6. Regurgitation of the 'complete feeding' after each feeding

  The mean of score during 3 days is considered.
• Number of wake up per night [ Time Frame: from 0 to 6 months ]
  Evaluation during 3 consecutive days every month.
• Total sleep time per day [ Time Frame: from 0 to 6 months ]
  Time in hours. Evaluation during 3 consecutive days every month.
• Plasma amino acid profile [ Time Frame: between 3rd and 4th month ]
  Methods : Liquid Chromatography and Tandem Mass Spectrometry (LC / MS / MS) List of amino acids : Taurine, Aspartic acid, Threonine, Serine, Asparagine, Glutamine acid, Glutamine, Glycine, Alanine, Citrulline, Valine, Cystine, Methionine, Isoleucine, Leucine, Tyrosine, Phenylalanine, Beta aminoisobutyric acid, Ornithine, 1-Methyl-Histidine, Histidine, Lysine, 3-methyl-Histidine, Arginine, Hydroxyproline, Proline
• Metabolomic analysis from plasma and urine samples [ Time Frame: between 3rd and 4th month ]
  Non-targeted analysis : evaluation of all small molecules in biological system, such as amino acids, sugars, alcohols, sugar phosphates, amines, fatty acids, polar lipids, hormones and vitamins, as well as specialized metabolites, such as phenolic compounds, flavonoids, monoterpenes, sesquiterpenes, polyketides, alkaloids, including xenobiotics. Methods : Liquid Chromatography and Mass Spectrometry (LC / MS)

From birth to 5 months, milk is the essential and unique food of the newborn. The French National Nutrition Program (PNNS) recommends exclusive breastfeeding "up to 6 months and at least 4 months for a healthy benefit". However, only 36% of infants 0-6 months of age are exclusively breastfed worldwide. Some mothers choose to give infant formula to their baby in the first few months of life. This decision may be a personal choice or be imposed by pathophysiological situations.

The nutritional requirements of the infant are specific, which implies adequate nutrition. Infant formulas and follow-up formulas are therefore complex products, specially developed for a group of vulnerable consumers. In fact, the compositional and information requirements for infant formula are highly regulated.

This study, defined as a pilot study, proposes to evaluate the innovative "TrueGreen" BIO infant formula based on a new whey extraction method on the growth and tolerance of infants from 0 to 6 months compared to the conventional BIO infant formula. As no growth and tolerance data are currently available for this new TrueGreen BIO formula, this study aims to determine them.

• Other: Breastfeeding
  Infants were breastfed during 3 months minimum. Data on growth and tolerance were collected. 10 out of 40 infants take a blood test to metabolome analysis
• Other: Conventional BIO Infant formula
  Infant were fed during 6 months with a conventional BIO infant formula. Data on growth and tolerance were collected. 10 out of 40 infants take a blood test to metabolome analysis
• Other: TrueGreen BIO infant formula
  Infant were fed during 6 months with the TrueGreen BIO infant formula. Data on growth and tolerance were collected. 10 out of 40 infants take a blood test to metabolome analysis

• Placebo Comparator: Breast milk
  group receiving breastfeeding
  Intervention: Other: Breastfeeding
• Active Comparator: infant formula conventional BIO
  infant formula with conventional whey BIO
  Intervention: Other: Conventional BIO Infant formula
• Active Comparator: infant formula BIO TrueGreen
  infant formula with whey BIO TrueGreen
  Intervention: Other: TrueGreen BIO infant formula

Inclusion Criteria:

• 0 to 3 weeks
• Child followed by a general practitioner or pediatrician
• Informed consent form signed by the legal representatives of the subject
• Commitment of legal representatives to follow the constraints generated by the study
• Insured

Exclusion Criteria:

• Infant born prematurely before 37 weeks of amenorrhea
• Child allergic to cow's milk proteins
• Pathological pregnancy (hypertension, infection, gestational diabetes, etc.);
• Chronic or acute illness (metabolic or neuromuscular diseases, epilepsy, asthma, diabetes, digestive, renal, cardiac or haematological diseases);
• Incapacity for the legal representative(s) to understand or adhere to the protocol
• Subject involved in another clinical study or in an exclusion period from another study
• Legal representatives deprived of liberty
• Legal representatives in a position to judicial protection
• Weight of the subject according to age and sex, not included between the 3rd and the 97th percentile of the WHO Child Growth Standards
• Subject height according to age and sex, not between the 3rd and the 97th percentile of the WHO Child Growth Standards
• BMI of the subject according to age and sex, not included between the 3rd and the 97th percentile of the WHO Child Growth Standards
• Head circumference of the subject according to age and sex, not included between the 3rd and the 97th percentile of the WHO (World Health Organization) Child Growth Standards
• The investigator considers that the state of health or the concomitant treatments are not compatible with the good progress of the clinical study.