Introduction: Pityriasis lichenoides (PL) is an inflammatory dermatitis of undetermined origin consisting of specific papular lesions reflecting an "indolent" lymphoproliferative state.
The current classification is confusing because it mixes semiological and chronological notions.
The objectives of this study are to better describe the clinical, epidemiological, histological, phenotypic and evolutionary aspects of PL in an adult population.
Methods: Investigators will perform a retrospective cohort study including patients with clinical and histological diagnosis of PL from the coding of the Department of Pathology of Henri-Mondor Hospital and from medical records and photographs of lesions if available, between January 2012 and August 2018. A follow-up telephone interviews will also be proposed to each patient to collect evolution data. Photographs will be systematically reviewed as well as cutaneous samples and a genomic analysis will be performed.
Conclusion: Investigators would like to better understand clinical, histological features and evolutionary aspects of PL in an adult population.
Condition or disease |
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Pityriasis Lichenoides |
Study Type : | Observational |
Estimated Enrollment : | 52 participants |
Observational Model: | Cohort |
Time Perspective: | Retrospective |
Official Title: | Pityriasis Lichenoides: Anatomo-clinical Aspects and Follow-up Monocentric Retrospective Study |
Estimated Study Start Date : | May 1, 2019 |
Estimated Primary Completion Date : | November 1, 2019 |
Estimated Study Completion Date : | November 1, 2019 |
Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
Exclusion Criteria:
Contact: Saskia ORO, Doctor | +33 1 49 81 25 36 | saskia.oro@aphp.fr |
Principal Investigator: | Saskia ORO, Doctor | Assistance Publique Hôpitaux de Paris - CHU Henri Mondor - Créteil |
Tracking Information | |||||
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First Submitted Date | March 12, 2019 | ||||
First Posted Date | April 19, 2019 | ||||
Last Update Posted Date | April 19, 2019 | ||||
Estimated Study Start Date | May 1, 2019 | ||||
Estimated Primary Completion Date | November 1, 2019 (Final data collection date for primary outcome measure) | ||||
Current Primary Outcome Measures |
To study clinical Aspects of Pityriasis Lichenoides on a large series of adult patients [ Time Frame: It will be measured within 6 months of enrollment ] Epidemiological and and clinical aspect description of the lesions from medical charts and photographs: age, sex, suspected trigger of the disease, past medical history, frequency of necrotic lesions, topography of lesions, fever, altered general conditions, treatment modalities of the flare.
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Original Primary Outcome Measures | Same as current | ||||
Change History | No Changes Posted | ||||
Current Secondary Outcome Measures |
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Original Secondary Outcome Measures | Same as current | ||||
Current Other Pre-specified Outcome Measures | Not Provided | ||||
Original Other Pre-specified Outcome Measures | Not Provided | ||||
Descriptive Information | |||||
Brief Title | Pityriasis Lichenoides : Anatomo-clinical Aspects and Follow-up | ||||
Official Title | Pityriasis Lichenoides: Anatomo-clinical Aspects and Follow-up Monocentric Retrospective Study | ||||
Brief Summary |
Introduction: Pityriasis lichenoides (PL) is an inflammatory dermatitis of undetermined origin consisting of specific papular lesions reflecting an "indolent" lymphoproliferative state. The current classification is confusing because it mixes semiological and chronological notions. The objectives of this study are to better describe the clinical, epidemiological, histological, phenotypic and evolutionary aspects of PL in an adult population. Methods: Investigators will perform a retrospective cohort study including patients with clinical and histological diagnosis of PL from the coding of the Department of Pathology of Henri-Mondor Hospital and from medical records and photographs of lesions if available, between January 2012 and August 2018. A follow-up telephone interviews will also be proposed to each patient to collect evolution data. Photographs will be systematically reviewed as well as cutaneous samples and a genomic analysis will be performed. Conclusion: Investigators would like to better understand clinical, histological features and evolutionary aspects of PL in an adult population. |
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Detailed Description | Not Provided | ||||
Study Type | Observational | ||||
Study Design | Observational Model: Cohort Time Perspective: Retrospective |
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Target Follow-Up Duration | Not Provided | ||||
Biospecimen | Not Provided | ||||
Sampling Method | Non-Probability Sample | ||||
Study Population | Adults with Pityriasis Lichenoides | ||||
Condition | Pityriasis Lichenoides | ||||
Intervention | Not Provided | ||||
Study Groups/Cohorts | Not Provided | ||||
Publications * |
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* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline. |
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Recruitment Information | |||||
Recruitment Status | Unknown status | ||||
Estimated Enrollment |
52 | ||||
Original Estimated Enrollment | Same as current | ||||
Estimated Study Completion Date | November 1, 2019 | ||||
Estimated Primary Completion Date | November 1, 2019 (Final data collection date for primary outcome measure) | ||||
Eligibility Criteria |
Inclusion Criteria:
Exclusion Criteria:
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Sex/Gender |
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Ages | 18 Years and older (Adult, Older Adult) | ||||
Accepts Healthy Volunteers | No | ||||
Contacts | Contact information is only displayed when the study is recruiting subjects | ||||
Listed Location Countries | Not Provided | ||||
Removed Location Countries | |||||
Administrative Information | |||||
NCT Number | NCT03920696 | ||||
Other Study ID Numbers | APHP180538 | ||||
Has Data Monitoring Committee | No | ||||
U.S. FDA-regulated Product |
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IPD Sharing Statement |
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Responsible Party | Assistance Publique - Hôpitaux de Paris | ||||
Study Sponsor | Assistance Publique - Hôpitaux de Paris | ||||
Collaborators | Not Provided | ||||
Investigators |
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PRS Account | Assistance Publique - Hôpitaux de Paris | ||||
Verification Date | February 2019 |