- 基线尿血管紧张素II/肌酐比率[时间范围:基线]
尿血管紧张素II通过高度发达的放射免疫测定法对质谱法进行了良好验证,并标准化为尿肌酐,并通过可追溯到同位素稀释的质谱法可追踪的修饰JAFFE测定法进行了量化。报告中央趋势(例如平均值,中位数)和分散(例如,标准偏差,四分位间距,95%置信区间)的报告度量。
- 尿血管紧张素II/肌酐比率的变化[时间范围:基线至2年]
尿血管紧张素II通过高度发达的放射免疫测定法对质谱法进行了良好验证,并标准化为尿肌酐,并通过可追溯到同位素稀释的质谱法可追踪的修饰JAFFE测定法进行了量化。报告中央趋势(例如平均值,中位数)和分散(例如,标准偏差,四分位间距,95%置信区间)的报告度量。
- 基线尿血管紧张素转换酶2级[时间范围:基线]
使用已建立的基于荧光的方法测量首次早晨尿液样品中的血管紧张素转换酶2和酶活性。标准化为尿肌酐,通过可追溯到同位素稀释质谱法的修饰JAFFE测定法进行了定量。报告中央趋势(例如平均值,中位数)和分散(例如,标准偏差,四分位间距,95%置信区间)的报告度量。
- 变化尿血管紧张素转换酶2级[时间范围:基线至2年]
使用已建立的基于荧光的方法测量首次早晨尿液样品中的血管紧张素转换酶2和酶活性。标准化为尿肌酐,通过可追溯到同位素稀释质谱法的修饰JAFFE测定法进行了定量。报告中央趋势(例如平均值,中位数)和分散(例如,标准偏差,四分位间距,95%置信区间)的报告度量。
- 基线尿血管紧张素转换酶水平[时间范围:基线]
使用已建立的基于荧光的方法测量首先尿液样品中的血管紧张素转换酶含量和酶活性。标准化为尿肌酐,通过可追溯到同位素稀释质谱法的修饰JAFFE测定法进行了定量。报告中央趋势(例如平均值,中位数)和分散(例如,标准偏差,四分位间距,95%置信区间)的报告度量。
- 尿血管紧张素转换酶水平的变化[时间范围:基线至2年]
使用已建立的基于荧光的方法测量首先尿液样品中的血管紧张素转换酶含量和酶活性。标准化为尿肌酐,通过可追溯到同位素稀释质谱法的修饰JAFFE测定法进行了定量。报告中央趋势(例如平均值,中位数)和分散(例如,标准偏差,四分位间距,95%置信区间)的报告度量。
- 基线尿血管紧张素转换酶/血管紧张素转换酶2比率[时间范围:基线]
测量使用基于荧光的方法,测量首次早晨尿液样品中的血管紧张素转换酶和血管紧张素转换酶2含量和酶活性。报告中央趋势(例如平均值,中位数)和分散(例如,标准偏差,四分位间距,95%置信区间)的报告度量。
- 变化尿血管紧张素转换酶/血管紧张素转换酶2比率[时间范围:基线至2年]
测量使用基于荧光的方法,测量首次早晨尿液样品中的血管紧张素转换酶和血管紧张素转换酶2含量和酶活性。报告中央趋势(例如平均值,中位数)和分散(例如,标准偏差,四分位间距,95%置信区间)的报告度量。
- 基线血浆血管紧张素II水平[时间范围:基线]
血浆血管紧张素II通过高度发达的放射免疫测定法对质谱法进行了良好验证。报告中央趋势(例如平均值,中位数)和分散(例如,标准偏差,四分位间距,95%置信区间)的报告度量。
- 血浆血管紧张素II水平的变化[时间范围:基线至2年]
血浆血管紧张素II通过高度发达的放射免疫测定法对质谱法进行了良好验证。报告中央趋势(例如平均值,中位数)和分散(例如,标准偏差,四分位间距,95%置信区间)的报告度量。
- 基线血清血管紧张素转换酶2级[时间范围:基线]
使用已建立的基于荧光的方法在血清样品中测量血管紧张素转换酶2含量和酶活性。报告中央趋势(例如平均值,中位数)和分散(例如,标准偏差,四分位间距,95%置信区间)的报告度量。
- 血清血管紧张素转换酶2水平的变化[时间范围:基线至2年]
使用已建立的基于荧光的方法在血清样品中测量血管紧张素转换酶2含量和酶活性。报告中央趋势(例如平均值,中位数)和分散(例如,标准偏差,四分位间距,95%置信区间)的报告度量。
- 基线血清血管紧张素转换酶水平[时间范围:基线]
使用已建立的基于荧光的方法在血清样品中测量血管紧张素转换酶含量和酶活性。报告中央趋势(例如平均值,中位数)和分散(例如,标准偏差,四分位间距,95%置信区间)的报告度量。
- 血清血管紧张素转换酶水平的变化[时间范围:基线至2年]
Measure angiotensin-converting enzyme content and enzymatic activity in serum samples using established fluorescence-based methods. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Baseline Serum Angiotensin-Converting Enzyme/Angiotensin-Converting Enzyme 2 Ratio [ Time Frame: Baseline ]
Measure angiotensin-converting enzyme and angiotensin-converting enzyme 2 content and enzymatic activity in serum samples using established fluorescence-based methods. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Change in Serum Angiotensin-Converting Enzyme/Angiotensin-Converting Enzyme 2 Ratio [ Time Frame: Baseline through 2 years ]
Measure angiotensin-converting enzyme and angiotensin-converting enzyme 2 content and enzymatic activity in serum samples using established fluorescence-based methods. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Baseline Hyperuricemia [ Time Frame: Baseline ]
Serum uric acid quantified by a validated uricase assay. Hyperuricemia defined as ≥8.0 mg/dl, reported with relative measures (eg, risk ratio) and measures of dispersion (eg, 95 percent confidence interval).
- Change in Hyperuricemia [ Time Frame: Baseline through 2 years ]
Serum uric acid quantified by a validated uricase assay. Hyperuricemia defined as ≥8.0 mg/dl, reported with relative measures (eg, risk ratio) and measures of dispersion (eg, 95 percent confidence interval).
- Baseline Manual Blood Pressure Classification [ Time Frame: Baseline ]
Based on average of 3 manual blood pressure (BP) measurements per age-specific national guidelines and age, sex, and height-based BP percentile. Categorized as a 4-level ordinal variable: (1) normal, <90th percentile or <120/80 mmHg; (2) elevated BP, ≥90th to <95th percentile or 120-129/<80 mmHg; (3) stage 1 hypertension, ≥95th to <95th percentile + 12 mmHg or 130-139/80-89 mmHg; (4) stage 2 hypertension, ≥95th percentile + 12 mmHg or ≥140/90 mmHg). Report relative measures (eg, odds ratio) and measures of dispersion (eg, 95 percent confidence interval).
- Change in Manual Blood Pressure Classification [ Time Frame: Baseline through 2 years ]
Based on average of 3 manual blood pressure (BP) measurements per age-specific national guidelines and age, sex, and height-based BP percentile. Categorized as a 4-level ordinal variable: (1) normal, <90th percentile or <120/80 mmHg; (2) elevated BP, ≥90th to <95th percentile or 120-129/<80 mmHg; (3) stage 1 hypertension, ≥95th to <95th percentile + 12 mmHg or 130-139/80-89 mmHg; (4) stage 2 hypertension, ≥95th percentile + 12 mmHg or ≥140/90 mmHg). Report relative measures (eg, odds ratio) and measures of dispersion (eg, 95 percent confidence interval).
- Baseline Ambulatory Systolic Blood Pressure 24-Hour Load [ Time Frame: Baseline ]
Measured via ambulatory blood pressure (BP) monitoring. Proportion of systolic BP readings over a 24-hour period that are ≥95th percentile for height per national guidelines. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Change in Ambulatory Systolic Blood Pressure 24-Hour Load [ Time Frame: Baseline through 2 years ]
Measured via ambulatory blood pressure (BP) monitoring. Proportion of systolic BP readings over a 24-hour period that are ≥95th percentile for height per national guidelines. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Baseline Ambulatory Diastolic Blood Pressure 24-Hour Load [ Time Frame: Baseline ]
Measured via ambulatory blood pressure (BP) monitoring. Proportion of diastolic BP readings over a 24-hour period that are ≥95th percentile for height per national guidelines. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Change in Ambulatory Diastolic Blood Pressure 24-Hour Load [ Time Frame: Baseline through 2 years ]
Measured via ambulatory blood pressure (BP) monitoring. Proportion of diastolic BP readings over a 24-hour period that are ≥95th percentile for height per national guidelines. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Baseline Ambulatory Systolic Blood Pressure 24-Hour Index [ Time Frame: Baseline ]
Measured via ambulatory blood pressure (BP) monitoring. Defined as mean BP over 24-hour period divided by the 95th percentile for sex and height, per national guidelines. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Change in Ambulatory Systolic Blood Pressure 24-Hour Index [ Time Frame: Baseline through 2 years ]
Measured via ambulatory blood pressure (BP) monitoring. Defined as mean BP over 24-hour period divided by the 95th percentile for sex and height, per national guidelines. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Baseline Ambulatory Diastolic Blood Pressure 24-Hour Index [ Time Frame: Baseline ]
Measured via ambulatory blood pressure (BP) monitoring. Defined as mean BP over 24-hour period divided by the 95th percentile for sex and height, per national guidelines. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Change in Ambulatory Diastolic Blood Pressure 24-Hour Index [ Time Frame: Baseline through 2 years ]
Measured via ambulatory blood pressure (BP) monitoring. Defined as mean BP over 24-hour period divided by the 95th percentile for sex and height, per national guidelines. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Baseline Ambulatory Systolic Blood Pressure Awake Mean [ Time Frame: Baseline ]
Measured via ambulatory blood pressure (BP) monitoring. Average systolic BP while awake. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Change in Ambulatory Systolic Blood Pressure Awake Mean [ Time Frame: Baseline through 2 years ]
Measured via ambulatory blood pressure (BP) monitoring. Average systolic BP while awake. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Baseline Ambulatory Diastolic Blood Pressure Awake Mean [ Time Frame: Baseline ]
Measured via ambulatory blood pressure (BP) monitoring. Average diastolic BP while awake. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Change in Ambulatory Diastolic Blood Pressure Awake Mean [ Time Frame: Baseline through 2 years ]
Measured via ambulatory blood pressure (BP) monitoring. Average diastolic BP while awake. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Baseline Ambulatory Systolic Blood Pressure Awake Load [ Time Frame: Baseline ]
Measured via ambulatory blood pressure (BP) monitoring. Proportion of systolic BP readings while awake that are ≥95th percentile for height per national guidelines. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Change in Ambulatory Systolic Blood Pressure Awake Load [ Time Frame: Baseline through 2 years ]
Measured via ambulatory blood pressure (BP) monitoring. Proportion of systolic BP readings while awake that are ≥95th percentile for height per national guidelines. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Baseline Ambulatory Diastolic Blood Pressure Awake Load [ Time Frame: Baseline ]
Measured via ambulatory blood pressure (BP) monitoring. Proportion of diastolic BP readings while awake that are ≥95th percentile for height per national guidelines. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Change in Ambulatory Diastolic Blood Pressure Awake Load [ Time Frame: Baseline through 2 years ]
Measured via ambulatory blood pressure (BP) monitoring. Proportion of diastolic BP readings while awake that are ≥95th percentile for height per national guidelines. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Baseline Ambulatory Systolic Blood Pressure Awake Index [ Time Frame: Baseline ]
Measured via ambulatory blood pressure (BP) monitoring. Defined as mean BP while awake divided by the 95th percentile for sex and height, per national guidelines. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Change in Ambulatory Systolic Blood Pressure Awake Index [ Time Frame: Baseline through 2 years ]
Measured via ambulatory blood pressure (BP) monitoring. Defined as mean BP while awake divided by the 95th percentile for sex and height, per national guidelines. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Baseline Ambulatory Diastolic Blood Pressure Awake Index [ Time Frame: Baseline ]
Measured via ambulatory blood pressure (BP) monitoring. Defined as mean BP while awake divided by the 95th percentile for sex and height, per national guidelines. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Change in Ambulatory Diastolic Blood Pressure Awake Index [ Time Frame: Baseline through 2 years ]
Measured via ambulatory blood pressure (BP) monitoring. Defined as mean BP while awake divided by the 95th percentile for sex and height, per national guidelines. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Baseline Ambulatory Systolic Blood Pressure Asleep Mean [ Time Frame: Baseline ]
Measured via ambulatory blood pressure (BP) monitoring. Average systolic BP while asleep. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Change in Ambulatory Systolic Blood Pressure Asleep Mean [ Time Frame: Baseline through 2 years ]
Measured via ambulatory blood pressure (BP) monitoring. Average systolic BP while asleep. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Baseline Ambulatory Diastolic Blood Pressure Asleep Mean [ Time Frame: Baseline ]
Measured via ambulatory blood pressure (BP) monitoring. Average diastolic BP while asleep. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Change in Ambulatory Diastolic Blood Pressure Asleep Mean [ Time Frame: Baseline through 2 years ]
Measured via ambulatory blood pressure (BP) monitoring. Average diastolic BP while asleep. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Baseline Ambulatory Systolic Blood Pressure Asleep Load [ Time Frame: Baseline ]
Measured via ambulatory blood pressure (BP) monitoring. Proportion of systolic BP readings while asleep that are ≥95th percentile for height per national guidelines. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Change in Ambulatory Systolic Blood Pressure Asleep Load [ Time Frame: Baseline through 2 years ]
Measured via ambulatory blood pressure (BP) monitoring. Proportion of systolic BP readings while asleep that are ≥95th percentile for height per national guidelines. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range, 95 percent confidence interval).
- Baseline Ambulatory Diastolic Blood Pressure Asleep Load [ Time Frame: Baseline ]
Measured via ambulatory blood pressure (BP) monitoring. Proportion of diastolic BP readings while asleep that are ≥95th percentile for height per national guidelines. Report measures of central tendency (eg, mean, median) and dispersion (eg, standard deviation, interquartile range,