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出境医 / 临床实验 / 培唑帕尼辅助治疗对术后肾细胞癌的有效性和安全性研究
培唑帕尼辅助治疗对术后肾细胞癌的有效性和安全性研究
基本信息
| 登记号 | CTR20131447 | 试验状态 | 进行中 |
|---|---|---|---|
| 申请人联系人 | 卢启应 | 首次公示信息日期 | 2014-12-18 |
| 申请人名称 | Glaxo Operations UK Limited/ 葛兰素史克（中国）投资有限公司/ Glaxo Group Limited | ||
公示的试验信息
一、题目和背景信息
| 登记号 | CTR20131447 | ||
|---|---|---|---|
| 相关登记号 | |||
| 药物名称 | 培唑帕尼 | ||
| 药物类型 | 化学药物 | ||
| 临床申请受理号 | 企业选择不公示 | ||
| 适应症 | 肾细胞癌辅助治疗 | ||
| 试验专业题目 | 随机、双盲、安慰剂对照、III期研究评价培唑帕尼辅助治疗肾切除术后的局限期肾癌患者的有效性和安全性 | ||
| 试验通俗题目 | 培唑帕尼辅助治疗对术后肾细胞癌的有效性和安全性研究 | ||
| 试验方案编号 | VEG113387 | 方案最新版本号 | |
| 版本日期: | 方案是否为联合用药 | 企业选择不公示 | |
二、申请人信息
| 申请人名称 |
1
2
3
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|---|---|---|---|---|---|
| 联系人姓名 | 卢启应 | 联系人座机 | 021-61590309 | 联系人手机号 | |
| 联系人Email | apollo.l.lu@gsk.com | 联系人邮政地址 | 上海浦东张江哈雷路917弄1号楼 | 联系人邮编 | 201203 |
三、临床试验信息
1、试验目的
评价培唑帕尼作为辅助治疗对肾切除术后局限性或局部进展性肾细胞癌患者的有效性和安全性。
2、试验设计
| 试验分类 | 安全性和有效性 | 试验分期 | III期 | 设计类型 | 平行分组 |
|---|---|---|---|---|---|
| 随机化 | 随机化 | 盲法 | 双盲 | 试验范围 | 国际多中心试验 |
3、受试者信息
| 年龄 | 18岁(最小年龄)至 无岁(最大年龄) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 性别 | 男+女 | ||||||||||||
| 健康受试者 | 无 | ||||||||||||
| 入选标准 |
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| 排除标准 |
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4、试验分组
| 试验药 |
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|---|---|---|---|---|---|---|---|
| 对照药 |
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5、终点指标
| 主要终点指标及评价时间 |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 次要终点指标及评价时间 |
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6、数据安全监查委员会（DMC）
有
7、为受试者购买试验伤害保险
有
四、研究者信息
1、主要研究者信息
| 1 | 姓名 | Robert Motzer | 学位 | 职称 | 教授 | |
|---|---|---|---|---|---|---|
| 电话 | 001 (646) 422-4312 | motzerr@mskcc.org | 邮政地址 | 1275 York Avenue, New York, United States | ||
| 邮编 | 10065 | 单位名称 | Memorial Sloan-Kettering Cancer Ctr-New York-United States | |||
2、各参加机构信息
| 序号 | 机构名称 | 主要研究者 | 国家 | 省（州） | 城市 |
|---|---|---|---|---|---|
| 1 | Memorial Sloan-Kettering Cancer Ctr-New York-United States-C | Robert Motzer | United States | New York | New York |
| 2 | 北京大学第一医院 | 金杰 | 中国 | 北京 | 北京 |
| 3 | 中国医学科学院肿瘤医院 | 王金万 | 中国 | 北京 | 北京 |
| 4 | 上海交通大学医学院附属仁济医院 | 黄翼然 | 中国 | 上海 | 上海 |
| 5 | 天津肿瘤医院 | 姚欣 | 中国 | 天津 | 天津 |
| 6 | 北京大学第三医院 | 马潞林 | 中国 | 北京 | 北京 |
| 7 | 浙江大学医学院附属第一医院 | 谢立平 | 中国 | 浙江 | 杭州 |
| 8 | 复旦大学附属华山医院 | 丁强 | 中国 | 上海 | 上海 |
| 9 | 浙江大学医学院附属第二医院 | 杜传军 | 中国 | 浙江 | 杭州 |
| 10 | 上海瑞金医院 | 沈周俊 | 中国 | 上海 | 上海 |
| 11 | 华中科技大学同济医学院附属同济医院 | 叶章群 | 中国 | 湖北 | 武汉 |
| 12 | 复旦大学附属肿瘤医院 | 叶定伟 | 中国 | 上海 | 上海 |
| 13 | COIBA Centro de oncología e investig-Berazategui | Mirta Varela | Argentina | Buenos Aires | Berazategui |
| 14 | Instituto Alexander Fleming-Capital Federal | Matias Chacon | Argentina | Buenos Aires | Capital Federal |
| 15 | Hospital Alemán-Ciudad de Buenos Aires | Carlos Bas | Argentina | Buenos Aires | Ciudad de Buenos Aires |
| 16 | Instituto de Investigaciones Clinicas Cipolletti-Cipolletti | Juan Lacava | Argentina | Río Negro | Cipolletti |
| 17 | CER Instituto Medico-Quilmes | Mirta Varela | Argentina | Quilmes | Quilmes |
| 18 | Instituto Oncologico de Cordoba-Cordoba | Martin Richardet | Argentina | Córdova | Córdoba |
| 19 | Instituto Médico Especializado-Ciudad de Buenos Aires | Gustavo Jankilevich | Argentina | Buenos Aires | Ciudad de Buenos Aires |
| 20 | Centro Oncologico de Rosario-Rosario | Luis Fein | Argentina | Santa Fe | Rosario |
| 21 | CEMIC-Ciudad Autonoma de Bueno | Gonzalo Recondo | Argentina | Buenos Aires | Ciudad Autonoma de Bueno |
| 22 | Hospital Britanico de Buenos Aires-Ciudad Autónoma de Bueno | Ernesto Korbenfeld | Argentina | Buenos Aires | Ciudad Autonoma de Buenos Aires |
| 23 | Fundacion RUSCULLEDA-Córdoba | Norma Pilnik | Argentina | Córdova | Córdoba |
| 24 | ISIS Clinica Especializada-Santa Fe | Cesar Blajman | Argentina | Santa Fe | Santa Fe |
| 25 | Sanatorio de la Providencia-Ciudad Autonoma de Bueno | Guillermo Lerzo | Argentina | Buenos Aires | Ciudad Autónoma de Buenos Aires |
| 26 | Investigaciones Clinicas Ciudad Autonoma de Buenos-Buenos Aires | Guillermo Lerzo | Argentina | Buenos Aires | Ciudad Autónoma de Buenos Aires |
| 27 | Centro Medico San Roque-San Miguel de Tucuman | Juan Zarba | Argentina | San Miguel de Tucumán | San Miguel de Tucumán |
| 28 | Universitaetsklinik Innsbruck-Innsbruck | Hannes Steiner | Austria | Innsbruck | Innsbruck |
| 29 | LKH Salzburg-Salzburg | Günter Janetschek | Austria | Salzburg | Salzburg |
| 30 | LKH Salzburg-Salzburg | Richard Greil | Austria | Salzburg | Salzburg |
| 31 | AKH Wien-Vienna | Gero Kramer | Austria | Vienna | Vienna |
| 32 | LKH Graz-Graz | Georg Hutterer | Austria | Graz | Graz |
| 33 | KH Hietzing mit Neurolog. Zentrum Rosenhügel-Vienna | Klaus Geissler | Austria | Vienna | Vienna |
| 34 | Centre Hospitalier Universitaire de Liège-Liege | Christine Gennigens | Belgium | Liège | Liège |
| 35 | Clinique St Elisabeth-Namur | Jean-Charles Goeminne | Belgium | Namur | Namur |
| 36 | AZ St Augustinus-Wilrijk | Jean Vandebroek | Belgium | Wilrijk | Wilrijk |
| 37 | UZ Brussel-Brussel | Denis Schallier | Belgium | Jette | Jette |
| 38 | Heilig Hart Ziekenhuis 3-Roeselare | Filip Van Aelst | Belgium | Roeselare | Roeselare |
| 39 | JESSA Ziekenhuis Campus Virga Jesse-Hasselt | Eric Joosens | Belgium | Hasselt | Hasselt |
| 40 | Hospital Erasto Gaertner-Curitiba | Murilo Luz | Brazil | Paraná | Curitiba |
| 41 | Hospital Israelita Albert Einstein-Sao Paulo | Oren Smaletz | Brazil | Sao Paulo | Sao Paulo |
| 42 | Hospital das Clínicas da Universidade Federal-Belo Horizonte | Lucas Nogueira | Brazil | Minas Gerais | Belo Horizonte |
| 43 | Instituto Nacional do Cancer - INCA-Rio de Janeiro | Fabio Peixoto | Brazil | Rio De Janeiro | Rio de Janeiro |
| 44 | Hospital Sirio Libanes-Sao Paulo | Ciro Eduardo de Souza | Brazil | Sao Paulo | Sao Paulo |
| 45 | Universidade Estadual de Campinas (UNICAMP)-Campinas | Ubirajara Ferreira | Brazil | Sao Paulo | Campinas |
| 46 | Hospital Universitário Pedro Ernesto-UERJ-Rio de Janeiro | Ronaldo Damiao | Brazil | Rio De Janeiro | Rio De Janeiro |
| 47 | Instituto do Cancer do Estado de Sao Paulo-Sao Paulo | Carlos Dzik | Brazil | Sao Paulo | Sao Paulo |
| 48 | Fundacao PIO XII - Hospital de Cancer de Barretos-Barretos | Sergio Serrano | Brazil | Sao Paulo | Barretos |
| 49 | Clinica de Oncologia Medica-Sao Paulo | Ricardo Caponero | Brazil | Sao Paulo | Sao Paulo |
| 50 | Hospital de Caridade de Ijui-Ijui | Fabio Franke | Brazil | Rio Grande Do Sul | Ijui |
| 51 | Hospital santa marcelina-Sao Paulo | Roberto Rocha | Brazil | Sao Paulo | Sao Paulo |
| 52 | PUC-RS/Hospital Sao Lucas-Porto Alegre | Carlos Henrique | Brazil | Rio Grande Do Sul | Porto Alegre |
| 53 | Cross Cancer Institute-Edmonton | Scott North | Canada | Alberta | Edmonton |
| 54 | Tom Baker Cancer Centre-Calgary | Daniel Heng | Canada | Alberta | Calgary |
| 55 | London Health Sciences Centre- Lawson Health-London | Eric Winquist | Canada | Ontario | London |
| 56 | Ottawa Regional Cancer Centre-Ottawa | Martin Reaume | Canada | Ontario | Ottawa |
| 57 | Lakeridge Health-Oshawa | Pawel Zalewski | Canada | Ontario | Oshawa |
| 58 | Princess Margaret Hospital-Toronto | Jennifer Knox | Canada | Ontario | Toronto |
| 59 | CHUQ-Hotel Dieu de Quebec-Quebec | Louis Lacombe | Canada | Québec | Québec |
| 60 | The Moncton Hospital-Moncton | Hazem Assi | Canada | New Brunswick | Moncton |
| 61 | Queen Elizabeth II Health Sciences Centre 2-Halifax | Lori Wood | Canada | Nova Scotia | Halifax |
| 62 | Juravinski Cancer Centre-Hamilton | Anil Kapoor | Canada | Ontario | Hamilton |
| 63 | CHUM Hopital Notre Dame-Quebec | Denis Soulieres | Canada | Québec | Montreal |
| 64 | Vancouver Prostate Centre-Vancouver | Christian Kollmannsberger | Canada | British Columbia | Vancouver |
| 65 | Sunnybrook Health Sciences Centre-Toronto | Georg Bjarnason | Canada | Ontario | Toronto |
| 66 | Fundación Arturo López Pérez-Santiago-Chile-C | Pamela Salman | Chile | Región Metro De Santiago | Santiago |
| 67 | Instituto Oncologico-Vina del Mar-Chile-C | Pablo Gonzalez Mella | Chile | Valparaíso | Vina del Mar |
| 68 | Masarykova nemocnice-Usti nad Labem-Czech Republic-C | Milan Lysy | Czech Republic | Usti nad Labem | Usti nad Labem |
| 69 | VFN Praha 2-Praha 2-Czech Republic-C | Milada Zemanova | Czech Republic | Praha 2 | Praha 2 |
| 70 | Nemocnice Na Bulovce-Praha 8-Czech Republic-C | Vladimira Stahalova | Czech Republic | Praha 8 | Praha 8 |
| 71 | FNsP u sv. Anny-Brno-Czech Republic-C | Jana Katolicka | Czech Republic | Brno | Brno |
| 72 | FN Plzen 2-Plzen-Czech Republic-C | Jindrich Finek | Czech Republic | Plzen | Plzen |
| 73 | FN Hradec Kralove 5-Hradec Kralove-Czech Republic-C | Eugen Kubala | Czech Republic | Hradec Kralove | Hradec Kralove |
| 74 | FN Olomouc-Olomouc-Czech Republic-C | Bohuslav Melichar | Czech Republic | Olomouc | Olomouc |
| 75 | FNsP Ostrava- Poruba-Ostrava - Poruba-Czech Republic-C | David Feltl | Czech Republic | Ostrava - Poruba | Ostrava - Poruba |
| 76 | Masarykuv onkologicky ustav-Brno-Czech Republic-C | Jiri Tomasek | Czech Republic | Brno | Brno |
| 77 | Nemocnice Novy Jicin-Novy Jicin-Czech Republic-C | Hana Perkova | Czech Republic | Novy Jicin | Novy Jicin |
| 78 | Herlev Hospital-Herlev-Denmark-C | Poul Geertsen | Denmark | Herlev | Herlev |
| 79 | Aarhus Universitetshospital, Aarhus Sygehus-Aarhus-Denmark-C | Frede Donskov | Denmark | Aarhus | Aarhus |
| 80 | Odense Universitetshospital-Odense C-Denmark-C | Niels Jensen | Denmark | Odense C | Odense C |
| 81 | Centre Francois Baclesse-Caen cedex 5-France-C | Emmanuel Sevin | France | Caen Cedex 05 | Caen Cedex 05 |
| 82 | Institut Mutualiste Montsouris-Paris-France-C | Mostefa Bennamoun | France | Paris | Paris |
| 83 | Centre Eugène Marquis-Rennes-France-C | Brigitte Laguerre | France | Rennes | Rennes |
| 84 | CHU de Poitiers - Hopital de la Milétrie-Poitiers cedex-France-C | Jean-Marc Tourani | France | Poitiers Cedex | Poitiers Cedex |
| 85 | HUS - Nouvel Hopital Civil-Strasbourg cedex-France-C | Brigitte Duclos | France | Strasbourg Cedex | Strasbourg Cedex |
| 86 | Institut de Cancérologie Paul Papin-Angers cedex 9-France-C | Sophie Abadie-Lacourtoisie | France | Angers cedex 9 | Angers cedex 9 |
| 87 | Institut Cancérologie de l’Ouest - René Gauducheau-Saint-Herblain cedex-France-C | Frédéric Rolland | France | Saint Herblain | Saint Herblain |
| 88 | Hopital Européen Georges Pompidou-Paris cedex 15-France-C | Stéphane Oudard | France | Paris Cedex 15 | Paris Cedex 15 |
| 89 | Polyclinique Courlancy-Reims-France-C | Philippe Colin | France | Reims | Reims |
| 90 | CHRU de Tours - Hopital Bretonneau-Tours cedex 9-France-C | Claude Linassier | France | Tours Cedex 9 | Tours Cedex 9 |
| 91 | Clinique Sainte Marguerite-Hyeres-France-C | Jean-Francois | France | Hyeres | Hyeres |
| 92 | CHU de Montpellier - Hopital Saint-Eloi-Montpellier cedex 5-France-C | Delphine Topart | France | Montpellier Cedex 5 | Montpellier Cedex 5 |
| 93 | CHU de Bordeaux - Hopital Saint André-Bordeaux-France-C | Marine Gross-Goupil | France | Bordeaux | Bordeaux |
| 94 | Centre Léon Bérard-Lyon cedex 08-France-C | Sylvie Negrier | France | Lyon Cedex 08 | Lyon Cedex 08 |
| 95 | CHU de Marseille - Hopital de la Timone-Marseille cedex 5-France-C | Jean Laurent Deville | France | Marseille cedex 5 | Marseille cedex 5 |
| 96 | CHU de Besancon - Hopital Jean Minjoz-Besancon cedex-France-C | Antoine Thiery Vuillemin | France | Besancon cedex | Besancon cedex |
| 97 | Centre Jean Bernard - Clinique Victor Hugo-Le Mans-France-C | Eric Voog | France | Le Mans | Le Mans |
| 98 | Clinique Pasteur-Toulouse-France-C | Alain Gratet | France | Toulouse | Toulouse |
| 99 | Clinique Sainte Anne-Strasbourg cedex-France-C | Louis-Marie Dourthe | France | Strasbourg cedex | Strasbourg cedex |
| 100 | Gem. Praxis Drs. Woerner und Rudolph-Kirchheim-Germany-C | Robert Rudolph | Germany | Baden-Wuerttemberg | Kirchheim |
| 101 | Universitaetsklinikum Marburg-Urologie-Marburg-Germany-C | Axel Hegele | Germany | Hessen | Marburg |
| 102 | Praxis Dr. med. Jochen Wilke-Fuerth-Germany-C | Harald Wagner | Germany | Bayern | Fuerth |
| 103 | Helios Klinikum Erfurt-Urologie-Erfurt-Germany-C | Thomas Steiner | Germany | Freistaat Thüringen | Erfurt |
| 104 | Universitaetsklinikum Bonn-Urologie-Bonn-Germany-C | Stefan Hauser | Germany | Nordrhein-Westfalen | Bonn |
| 105 | Klinikum Offenbach GmbH-Urologische Klinik-Offenbach-Germany-C | Michael Lein | Germany | Hessen | Offenbach |
| 106 | Universitaetsklinikum Muenster-Urologie-Muenster-Germany-C | Edwin Herrmann | Germany | Nordrhein-Westfalen | Muenster |
| 107 | Uniklinik Schleswig-Holstein-Campus Luebeck-Urolog-Luebeck-Germany-C | Christian Doehn | Germany | Schleswig-Holstein | Luebeck |
| 108 | Universitaetsklinikum des Saarlandes-Urologie-Homburg/Saar-Germany-C | Stefan Siemer | Germany | Saarland | Homburg |
| 109 | Universitaetsklinikum Ulm-Urologie-Ulm-Germany-C | Mark Schrader | Germany | Baden-Wuerttemberg | Ulm |
| 110 | Praxis Dr. med. Ralf Eckert-Eisleben-Germany-C | Ralf Eckert | Germany | Sachsen-Anhalt | Eisleben |
| 111 | Charite-Campus Mitte-Urologie-Berlin-Germany-C | Ahmed Magheli | Germany | Berlin | Berlin |
| 112 | Universitaetsklinikum Aachen-Urologie-Aachen-Germany-C | Axel Heidenreich | Germany | Nordrhein-Westfalen | Aachen |
| 113 | Praxis Dr. med. Goetz Geiges-Berlin-Germany-C | Goetz Geiges | Germany | Berlin | Berlin |
| 114 | Katharinenhospital Stuttgart-Stuttgart-Germany-C | Jan Schleicher | Germany | Baden-Wuerttemberg | Stuttgart |
| 115 | Universitaetsklinikum Jena-Urologie-Jena-Germany-C | Marc-Oliver Grimm | Germany | Thueringen | Jena |
| 116 | Krankenhaus Am Urban-Berlin-Germany-C | Wolfgang Pokrzywnitzki | Germany | Berlin | Berlin |
| 117 | Waldkrankenhaus St. Marien-Erlangen-Germany-C | Peter Goebell | Germany | Bayern | Erlangen |
| 118 | Praxis Dr. med. Toralf Kellner-Plauen-Germany-C | Toralf Kellner | Germany | Sachsen | Plauen |
| 119 | Klinikum rechts der Isar-Urologie-Muenchen-Germany-C | Juergen Gschwend | Germany | Bayern | Muenchen |
| 120 | Klinikum der J. W. Goethe-Universitaet-Med. K. II-Frankfurt-Germany-C | Lothar Bergmann | Germany | Hessen | Frankfurt |
| 121 | Kreiskrankenhaus Sigmaringen-Urologie-Sigmaringen-Germany-C | Zoltan Varga | Germany | Baden-Wuerttemberg | Sigmaringen |
| 122 | Praxis Dr. med. Hans Werner Tessen-Goslar-Germany-C | Hans Werner Tessen | Germany | Niedersachsen | Goslar |
| 123 | Universitaetsklinikum der GHS Essen-Tumorforschung-Essen-Germany-C | Johannes Meiler | Germany | Nordrhein-Westfalen | Essen |
| 124 | Martin-Luther-Universitaet Halle-Urologie-Halle-Germany-C | Paolo Fornara | Germany | Sachsen-Anhalt | Halle |
| 125 | Johannes-Gutenberg-Universitaet Mainz-Urologie-Mainz-Germany-C | Christian Hampel | Germany | Rheinland-Pfalz | Mainz |
| 126 | Studienzentrum Onkologie Ravensburg im Brustzentru-Ravensburg-Germany-C | Thomas Decker | Germany | Baden-Wuerttemberg | Ravensburg |
| 127 | Staedtische Kliniken Neuss Lukaskrankenhaus-Urol.-Neuss-Germany-C | Thomas Otto | Germany | Nordrhein-Westfalen | Neuss |
| 128 | Caritas-Krankenhaus St. Josef-Urologie-Regensburg-Germany-C | Stefan Denzinger | Germany | Bayern | Regensburg |
| 129 | Duisburger Fachaerztegemeinschaft Urologie-Duisburg-Germany-C | Eva Hellmis | Germany | Nordrhein-Westfalen | Duisburg |
| 130 | Klinikum Nordoberpfalz-Weiden-Urologie-Weiden-Germany-C | Theodor Klotz | Germany | Bayern | Weiden |
| 131 | Zeisigwaldkliniken Bethanien-Urologie-Chemnitz-Germany-C | Dirk Fahlenkamp | Germany | Sachsen | Chemnitz |
| 132 | Universitaetsklinikum Eppendorf-Urologie-Hamburg-Germany-C | Roman Heuer | Germany | Hamburg | Hamburg |
| 133 | Medizinische Hochschule Hannover-Urologie-Hannover-Germany-C | Markus Kuczyk | Germany | Niedersachsen | Hannover |
| 134 | Diakonissenkrankenhaus Dessau gGmbH-Urologie-Dessau-Germany-C | Udo Rebmann | Germany | Sachsen-Anhalt | Dessau |
| 135 | Klinikum Bremen-Mitte gGmbH-Urologische Klinik-Bremen-Germany-C | Sebastian Melchior | Germany | Bremen | Bremen |
| 136 | Universitaetsklinikum Tuebingen-Urologie-Tuebingen-Germany-C | Arnulf Stenzl | Germany | Baden-Wuerttemberg | Tuebingen |
| 137 | Klinikum Braunschweig-Urologische Klinik-Braunschweig-Germany-C | Peter Hammerer | Germany | Niedersachsen | Braunschweig |
| 138 | Kliniken Maria Hilf-Klinik fuer Urologie-Moenchengladbach-Germany-C | Herbert Sperling | Germany | Nordrhein-Westfalen | Moenchengladbach |
| 139 | Marien-Krankenhaus-Bergisch Gladbach-Germany-C | Stefan Machtens | Germany | Nordrhein-Westfalen | Bergisch Gladbach |
| 140 | Gem. Praxis Drs. Nusch und Kalhori-Velbert-Germany-C | Arnd Nusch | Germany | Nordrhein-Westfalen | Velbert |
| 141 | Klinikum Grosshadern-Urologie-Muenchen-Germany-C | Michael Staehler | Germany | Bayern | Muenchen |
| 142 | VITURO, Ges.f. klinische Studien, Ur-Leipzig-Germany-C | Detlef Nietzsch | Germany | Sachsen | Leipzig |
| 143 | University Hospital of Patras-Patra-Greece-C | Haralabos Kalofonos | Greece | Rio-Patras | Rio-Patras |
| 144 | University Hospital of Heraklion-Heraklion, Crete-Greece-C | Vassilis Georgoulias | Greece | Heraklion, Crete | Heraklion, Crete |
| 145 | General Hospital of Athens | Aristotelis Bamias | Greece | Athens | Athens |
| 146 | Agios Savvas Hospital-Athens-Greece-C | Anastasios Thanos | Greece | Athens | Athens |
| 147 | Euromedica General Clinic of Thessaloniki-Thessaloniki-Greece-C |
